2024
Selective utilization of glucose metabolism guides mammalian gastrulation
Cao D, Bergmann J, Zhong L, Hemalatha A, Dingare C, Jensen T, Cox A, Greco V, Steventon B, Sozen B. Selective utilization of glucose metabolism guides mammalian gastrulation. Nature 2024, 634: 919-928. PMID: 39415005, PMCID: PMC11499262, DOI: 10.1038/s41586-024-08044-1.Peer-Reviewed Original ResearchConceptsCellular metabolismMammalian gastrulationHexosamine biosynthetic pathwayTranscription factor networksCellular signaling pathwaysSignaling morphogensGlucose metabolismCellular programmeBiosynthetic pathwayFate acquisitionCell fateHousekeeping natureGenetic mechanismsMesoderm migrationFactor networksERK activationExpression patternsSignaling pathwayDevelopmental processesStem cell modelCell typesSpecialized functionsDevelopmental contextMammalian embryosMouse embryos
2014
Cell fate regulation during preimplantation development: A view of adhesion-linked molecular interactions
Sozen B, Can A, Demir N. Cell fate regulation during preimplantation development: A view of adhesion-linked molecular interactions. Developmental Biology 2014, 395: 73-83. PMID: 25176042, DOI: 10.1016/j.ydbio.2014.08.028.Peer-Reviewed Original ResearchConceptsCell fate regulationEarly mammalian embryoFate regulationCell fate specificationMammalian embryosJunctional complexesEvaluate transcriptional differencesTranscriptional networksFate specificationCell polarityIntercellular junctional complexesPreimplantation developmentCellular diversificationTranscriptional differencesDiversification processEmbryonic lineagesEarly embryosCell adhesionDevelopmental processesEarly morphogenesisLineage commitmentIdentical cellsCell positionMolecular interactionsCells