Temporal Analysis of Hepatitis C Virus Cell Entry with Occludin Directed Blocking Antibodies
Sourisseau M, Michta ML, Zony C, Israelow B, Hopcraft SE, Narbus CM, Martín A, Evans MJ. Temporal Analysis of Hepatitis C Virus Cell Entry with Occludin Directed Blocking Antibodies. PLOS Pathogens 2013, 9: e1003244. PMID: 23555257, PMCID: PMC3605286, DOI: 10.1371/journal.ppat.1003244.Peer-Reviewed Original ResearchConceptsHCV cell entryHepatitis C virusClaudin-1Complete HCV life cycleCell entryTight junction protein claudin-1HCV life cyclePost-binding stageMiR-122 expressionHepatitis C virus cell entryHepG2 cellsNumerous host factorsVirus cell entryHCV therapyLiver diseaseC virusInfection assaysBlocking antibodiesHCV isolatesSR-BIHost cell entryHost factorsUtilization differencesMajor causeOccludin