Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors
Israelow B, Mullokandov G, Agudo J, Sourisseau M, Bashir A, Maldonado AY, Dar AC, Brown BD, Evans MJ. Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors. Nature Communications 2014, 5: 5408. PMID: 25403145, PMCID: PMC4236719, DOI: 10.1038/ncomms6408.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceHepacivirusHepatitis CHumansLiverMicroRNAsMolecular Sequence DataPoint MutationVirus ReplicationConceptsMiR-122Hepatitis C virus replicationRecent clinical trialsC virus replicationMiR-122 inhibitionMiR-122 inhibitorClinical trialsHCV replicationMiR-122 knockdownHCV drugsHCV variantsHCVHCV genomeViral titresVirus replicationNext-generation sequencingTransient inhibitionVirus geneticsViral adaptationViral sequencesInhibitionNucleotide changesSingle nucleotide changePatientsTitres