1999
Opposite modulation of cortical N-methyl-d-aspartate receptor-mediated responses by low and high concentrations of dopamine
Zheng P, Zhang X, Bunney B, Shi W. Opposite modulation of cortical N-methyl-d-aspartate receptor-mediated responses by low and high concentrations of dopamine. Neuroscience 1999, 91: 527-535. PMID: 10366010, DOI: 10.1016/s0306-4522(98)00604-6.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsBenzazepinesDizocilpine MaleateDopamineDopamine AgonistsDopamine AntagonistsDose-Response Relationship, DrugExcitatory Amino Acid AntagonistsIn Vitro TechniquesMaleMembrane PotentialsPrefrontal CortexPyramidal CellsQuinoxalinesQuinpiroleRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateConceptsN-methyl-D-aspartate functionN-methyl-D-aspartate currentsN-methyl-D-aspartate (NMDA) receptor-mediated transmissionN-methyl-D-aspartate receptor-mediated responsesN-methyl-D-aspartate receptorsHigh concentrations dopamineReceptor-mediated transmissionD2 agonist quinpiroleD1 agonist SKF38393D1-like receptorsD-aspartate antagonistGlutamate-mediated neurotransmissionD2-like receptorsPresence of tetrodotoxinEffects of dopamineReceptor-mediated responsesWhole-cell recordingsD-aspartate agonistMedial prefrontal cortexBrief local applicationDizocilpine maleateAgonist SKF38393Concentration of dopamineCortical dopamineGlutamate transmission
1997
D1–D2 Interaction in Feedback Control of Midbrain Dopamine Neurons
Shi W, Smith P, Pun C, Millet B, Bunney B. D1–D2 Interaction in Feedback Control of Midbrain Dopamine Neurons. Journal Of Neuroscience 1997, 17: 7988-7994. PMID: 9315916, PMCID: PMC6793911, DOI: 10.1523/jneurosci.17-20-07988.1997.Peer-Reviewed Original ResearchConceptsD2-like receptorsDA cellsDA autoreceptorsDA neuronsD1 agonistLow dosesDopamine D1-like receptorsD1 inhibitionD1 effectNigral DA cellsMidbrain DA neuronsD2 agonist quinpiroleD1-like receptorsDA receptor subtypesMidbrain dopamine neuronsOnly low dosesDA receptorsEndogenous DAAgonist quinpiroleD2 agonistIntranigral applicationDopamine neuronsReceptor subtypesRat preparationTarget neuronsCharacterization of dopamine‐induced depolarization of prefrontal cortical neurons
Shi W, Zheng P, Liang X, Bunney B. Characterization of dopamine‐induced depolarization of prefrontal cortical neurons. Synapse 1997, 26: 415-422. PMID: 9215600, DOI: 10.1002/(sici)1098-2396(199708)26:4<415::aid-syn9>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsEffects of dopaminePFC neuronsDA agonistsPrefrontal cortexAtypical antipsychotic drug clozapinePrefrontal cortical neuronsRat brain slicesAntipsychotic drug clozapineWhole-cell recordingsPFC pyramidal cellsSynaptic blockadeDA receptorsBeta antagonistDA antagonistsSubstantia nigraCortical neuronsPyramidal cellsBrain slicesDrug clozapineCell recordingsNeuronsAntagonistNonspecific mechanismsDopamineDepolarizationDopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs
Grace A, Bunney B, Moore H, Todd C. Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs. Trends In Neurosciences 1997, 20: 31-37. PMID: 9004417, DOI: 10.1016/s0166-2236(96)10064-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntipsychotic AgentsDopamineDopamine AgonistsMembrane PotentialsModels, NeurologicalConceptsDepolarization blockAntipsychotic drugsDopamine systemNigrostriatal dopamine systemWeeks of treatmentExtrapyramidal side effectsAntipsychotic drug efficacyDopamine receptor antagonistDrug treatment resultsMesolimbic dopamine neuronsTreatment of schizophreniaDopamine neuron firingReceptor blockadeDopamine neuronsTherapeutic impactSide effectsClinical actionsDrug AdministrationTherapeutic efficacyTreatment resultsDrug efficacyTherapeutic actionPotential mechanismsDrugsEfficacy
1995
Ritanserin, a 5-HT2A/2C antagonist, reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons.
Shi W, Nathaniel P, Bunney B. Ritanserin, a 5-HT2A/2C antagonist, reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons. Journal Of Pharmacology And Experimental Therapeutics 1995, 274: 735-40. PMID: 7636736.Peer-Reviewed Original ResearchConceptsEffects of ritanserinBasal firing rateDA autoreceptorsDA neuronsDA agonistsP-chlorophenylalanineSubstantia nigra DA neuronsSingle-unit recording techniquesChloral hydrate-anesthetized ratsFiring rateDA agonist quinpiroleDirect DA agonistsIndirect DA agonistPostsynaptic D2 receptorsExtrapyramidal side effectsD2-like receptorsSignificant therapeutic effectAgonist-induced inhibitionMidbrain dopamine neuronsMidbrain dopamine systemAgonist quinpiroleDA antagonistsMDL 100907Receptor antagonistDopamine neurons