1975
Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine
Svensson T, Bunney B, Aghajanian G. Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine. Brain Research 1975, 92: 291-306. PMID: 1174954, DOI: 10.1016/0006-8993(75)90276-0.Peer-Reviewed Original ResearchConceptsNE neuronsAgonist clonidineHigh dosesMidbrain dorsal raphe nucleusAlpha-adrenergic agonist clonidineSingle-unit recording techniquesBrain NE neuronsClonidine-induced depressionDorsal raphe nucleusAdrenergic agonist clonidineBrain norepinephrineRaphe neuronsIntravenous clonidineAdrenergic transmissionSerotonergic neuronsDepressant effectDopaminergic neuronsRaphe nucleusSpontaneous firingLocus coeruleusClonidineLow doseL-amphetamineAdrenergic receptorsNeurons
1974
Noradrenergic neurons: Morphine inhibition of spontaneous activity
Korf J, Bunney B, Aghajanian G. Noradrenergic neurons: Morphine inhibition of spontaneous activity. European Journal Of Pharmacology 1974, 25: 165-169. PMID: 4435020, DOI: 10.1016/0014-2999(74)90045-4.Peer-Reviewed Original ResearchConceptsLocus coeruleusMorphine sulfateFiring rateNeuronal activitySpontaneous activityNoradrenergic neuron activityNorepinephrine-containing neuronsNoradrenergic neuronal activityLocus coeruleus cellsSpontaneous firing rateDorsal raphe nucleusAnalgesic actionMorphine inhibitionSerotonergic neuronsRaphe nucleusMorphine antagonistNoxious stimuliNE cellsNeuron activityCoeruleusMorphineNeuronsNaloxoneInhibitionCells