1976
d-Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback Pathway
Bunney B, Achajanian G. d-Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback Pathway. Science 1976, 192: 391-393. PMID: 1257777, DOI: 10.1126/science.1257777.Peer-Reviewed Original ResearchConceptsD-amphetamineDepressant effectDopaminergic cell activityIntravenous d-amphetamineCentral dopaminergic neuronsStriato-nigral pathwayNeuronal feedback loopMicroiontophoretic applicationDopaminergic neuronsDopaminergic cellsCell activitySignificant slowingFeedback pathwaysPrevious dataCellsLesionsPathwayNeurons
1974
A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neurons
Bunney B, Aghajanian G. A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neurons. Life Sciences 1974, 15: 309-318. PMID: 4549921, DOI: 10.1016/0024-3205(74)90221-5.Peer-Reviewed Original ResearchConceptsChlorpromazine sulfoxideSingle-unit recording techniquesAnti-psychotic propertyCentral dopaminergic neuronsVentral tegmental neuronsPossible clinical importanceEffect of chlorpromazineA10 neuronsDopaminergic neuronsAntipsychotic efficacyPlasma levelsTegmental neuronsAntipsychotic agentsTherapeutic effectAntipsychotic propertiesClinical importanceEquivalent dosesRecording techniquesChlorpromazineNeuronsDepressionPreliminary studyPrevious findingsSulfoxide levelsChlorpromazine metabolites
1973
CENTRAL DOPAMINERGIC NEURONS: NEUROPHYSIOLOGICAL IDENTIFICATION AND RESPONSES TO DRUGS**This research was supported by NIMH Grant MH-17871, USPHS Research Scientist Development Award MH-14459 (to G. K. A.), and the State of Connecticut.
AGHAJANIAN G, BUNNEY B. CENTRAL DOPAMINERGIC NEURONS: NEUROPHYSIOLOGICAL IDENTIFICATION AND RESPONSES TO DRUGS**This research was supported by NIMH Grant MH-17871, USPHS Research Scientist Development Award MH-14459 (to G. K. A.), and the State of Connecticut. 1973, 643-648. DOI: 10.1016/b978-0-08-017922-3.50120-9.Peer-Reviewed Original ResearchDopaminergic neuronsNeurophysiological identificationCentral dopaminergic neuronsSubstantia nigraDopaminergic cellsReticular formationRat brainRed nucleusAction potentialsZR cellsFiring patternsNeuronsExtracellular action potentialsRegular rhythmChloral hydrateLonger durationBursting patternDrugsState of ConnecticutCellsResponseAnesthesiaDopaminergicHalothaneBrain