2003
Regulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteins
Zhang J, Li W, Sanders MA, Sumpio BE, Asit P, Basson MD. Regulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteins. The FASEB Journal 2003, 17: 1-22. PMID: 12626437, DOI: 10.1096/fj.02-0663fje.Peer-Reviewed Original ResearchMeSH KeywordsCaco-2 CellsCell AdhesionCell DivisionCell LineCollagen Type ICollagen Type IVEnzyme ActivationEpithelial CellsExtracellular Matrix ProteinsFibronectinsFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesHumansIntegrin alpha5Integrin alphaVIntestinal MucosaLamininMitogen-Activated Protein KinasesPhosphorylationProtein-Tyrosine KinasesStress, MechanicalConceptsExtracellular signal-regulated protein kinaseMatrix proteinsIntestinal epithelial responsesHuman intestinal epithelial proliferationSignal-regulated protein kinaseJun N-terminal kinaseFocal adhesion kinaseIntestinal epithelial biologyMatrix-dependent mannerN-terminal kinaseExtracellular matrix proteinsEpithelial responseCaco-2 proliferationCaco-2BBe cellsIntestinal epithelial proliferationAdhesion kinaseEpidermal growth factorProtein kinaseERK activationEpithelial biologyEpithelial cell proliferationIntegrin subunitsKinaseAnti-integrin antibodiesMEK blockade
2000
Effects of glutamine isomers on human (Caco-2) intestinal epithelial proliferation, strain-responsiveness, and differentiation
Murnin M, Kumar A, di Li G, Brown M, Sumpio B, Basson M. Effects of glutamine isomers on human (Caco-2) intestinal epithelial proliferation, strain-responsiveness, and differentiation. Journal Of Gastrointestinal Surgery 2000, 4: 435-442. PMID: 11058864, DOI: 10.1016/s1091-255x(00)80025-6.Peer-Reviewed Original ResearchMeSH KeywordsCaco-2 CellsCell CountCell DifferentiationCell DivisionDietary SupplementsDipeptidyl-Peptidases and Tripeptidyl-PeptidasesEnteral NutritionEnterocytesEnzyme InhibitorsEpithelial CellsFastingGamma-GlutamyltransferaseGastrointestinal MotilityGlutamineHumansIntestinal MucosaIsomerismIsoxazolesPeristalsisStatistics, NonparametricStress, MechanicalConceptsGlutamine supplementationIntestinal epithelial cellsBowel motilityGut mucosaCaco-2 proliferationEpithelial cellsCaco-2L-glutamine supplementationGlutamine metabolismCaco-2 intestinal epithelial cellsIntestinal epithelial proliferationFrequency-dependent mannerHuman Caco-2 intestinal epithelial cellsCaco-2 cellsEnteral feedingL-glutamineHT-29 cellsVillous motilitySelective antagonistEpithelial proliferationLess potencyVivo frequencyMalignant colonocytesHuman colonocytesMaximal stimulation