2018
Regulation of Yes-Associated Protein by Laminar Flow
Chitragari G, Shalaby SY, Sumpio BJ, Kurita J, Sumpio BE. Regulation of Yes-Associated Protein by Laminar Flow. Annals Of Vascular Surgery 2018, 52: 183-191. PMID: 29758328, DOI: 10.1016/j.avsg.2018.03.002.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingCell ShapeCells, CulturedCytoskeletonDown-RegulationHuman Umbilical Vein Endothelial CellsHumansMechanotransduction, CellularPhosphoproteinsPhosphorylationProteolysisPulsatile FlowRegional Blood FlowStress, MechanicalTime FactorsTranscription FactorsYAP-Signaling ProteinsConceptsHuman umbilical vein endothelial cellsTotal YAPExposure of HUVECsRelease of mediatorsYAP levelsSignificant decreaseUbiquitin-proteasome system inhibitorsUmbilical vein endothelial cellsEndothelial cell proliferationVein endothelial cellsVascular healthSystem inhibitorsYes-Associated ProteinDisease modulationIntimal hyperplasiaDisturbed flowEndothelial cellsBlood vesselsDisease statesPotential targetCell proliferationProteasome-independent mechanismExposureKey regulatorPYAP
1999
Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress
Li S, Chen B, Azuma N, Hu Y, Wu S, Sumpio B, Shyy J, Chien S. Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress. Journal Of Clinical Investigation 1999, 103: 1141-1150. PMID: 10207166, PMCID: PMC408275, DOI: 10.1172/jci5367.Peer-Reviewed Original ResearchAnimalsBiological TransportCalcium-Calmodulin-Dependent Protein KinasesCattleCdc42 GTP-Binding ProteinCell Cycle ProteinsCells, CulturedCytoskeletonEndothelium, VascularGTP PhosphohydrolasesGTP-Binding ProteinsIntracellular Signaling Peptides and ProteinsJNK Mitogen-Activated Protein KinasesMitogen-Activated Protein KinasesPhysical StimulationProtein Serine-Threonine KinasesResponse ElementsRho GTP-Binding ProteinsRhoA GTP-Binding ProteinRho-Associated KinasesTranscription Factor AP-1
1998
Molecular Basis for Tissue Expansion: Clinical Implications for the Surgeon
Takei T, Mills I, Arai K, Sumpio B. Molecular Basis for Tissue Expansion: Clinical Implications for the Surgeon. Plastic & Reconstructive Surgery 1998, 102: 247-258. PMID: 9655439, DOI: 10.1097/00006534-199807000-00044.Peer-Reviewed Original Research
1991
Morphological response of human endothelial cells subjected to cyclic strain in vitro
Iba T, Sumpio B. Morphological response of human endothelial cells subjected to cyclic strain in vitro. Microvascular Research 1991, 42: 245-254. PMID: 1779881, DOI: 10.1016/0026-2862(91)90059-k.Peer-Reviewed Original Research