2000
Functional parathyroid hormone receptors are present in an umbilical vein endothelial cell line
Isales C, Sumpio B, Bollag R, Zhong Q, Ding K, Du W, Rodriguez-Commes J, Lopez R, Rosales O, Gasalla-Herraiz J, McCarthy R, Barrett P. Functional parathyroid hormone receptors are present in an umbilical vein endothelial cell line. AJP Endocrinology And Metabolism 2000, 279: e654-e662. PMID: 10950835, DOI: 10.1152/ajpendo.2000.279.3.e654.Peer-Reviewed Original ResearchMeSH KeywordsCalciumCell LineChromatography, High Pressure LiquidCyclic AMPEndothelin-1Endothelium, VascularFluorescent DyesFura-2Glyceraldehyde-3-Phosphate DehydrogenasesHumansInositol PhosphatesParathyroid HormoneReceptors, Parathyroid HormoneReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionThymidineUmbilical VeinsConceptsParathyroid hormoneUmbilical vein endothelial cell lineParathyroid hormone receptorEndothelial cell lineHormone receptorsVascular smooth muscle relaxationEndothelin-1 secretionSmooth muscle relaxationVascular smooth muscleHuman umbilical vein endothelial cell lineCell linesCellular cAMP contentPossible direct effectPeptide receptor mRNAEndothelium-derived cellsBlood pressureContinuous infusionMuscle relaxationIntracellular calciumSmooth muscleReceptor mRNAHormone exposureVascular endotheliumEndothelial cellsCAMP content
1994
ENDOTHELIN-STIMULATED MONOCYTE SUPERNATANTS ENHANCE NEUTROPHIL SUPEROXIDE PRODUCTION
Huribal M, Kumar R, Cunningham M, Sumpio B, McMillen M. ENDOTHELIN-STIMULATED MONOCYTE SUPERNATANTS ENHANCE NEUTROPHIL SUPEROXIDE PRODUCTION. Shock 1994, 1: 184-187. PMID: 7735949, DOI: 10.1097/00024382-199403000-00005.Peer-Reviewed Original ResearchConceptsEndothelin-1Neutrophil superoxide productionIL-8Monocyte supernatantsSuperoxide productionInterleukin-8 contentHuman peripheral blood monocytesPotent neutrophil activatorVascular smooth musclePeripheral blood monocytesIncubation of neutrophilsInterleukin-6M ETNeutrophil activatorProstaglandin E2Smooth muscleVasoconstrictive peptideBlood monocytesMonocytesBasal levelsNeutrophilsSupernatantH incubationDirect effectEndothelinChronic Cyclic Strain Reduces Adenylate Cyclase Activity and Stimulatory G Protein Subunit Levels in Coronary Smooth Muscle Cells
Wiersbitzky M, Mills I, Sumpio B, Gewirtz H. Chronic Cyclic Strain Reduces Adenylate Cyclase Activity and Stimulatory G Protein Subunit Levels in Coronary Smooth Muscle Cells. Experimental Cell Research 1994, 210: 52-55. PMID: 8269996, DOI: 10.1006/excr.1994.1008.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSmooth muscle cellsAdenylate cyclase activityCoronary vascular smooth muscle cellsMuscle cellsCyclase activityChronic cyclic strainG protein subunit levelsCoronary smooth muscle cellsProtein steady-state levelsCoronary smooth muscleCultured smooth muscle cellsSteady-state levelsPorcine coronary arteriesCoronary arteryCoronary circulationBeta levelsCycles/minProtein subunit levelsSmooth muscleGi alphaIntravascular pressureEffector pathwaysUnstretched cellsSubunit levels
1990
Mechanosensitive adenylate cyclase activity in coronary vascular smooth muscle cells
Mills I, Letsou G, Rabban J, Sumpio B, Gewirtz H. Mechanosensitive adenylate cyclase activity in coronary vascular smooth muscle cells. Biochemical And Biophysical Research Communications 1990, 171: 143-147. PMID: 2393388, DOI: 10.1016/0006-291x(90)91368-3.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSmooth muscle cellsCoronary vascular smooth muscle cellsMuscle cellsCyclase activityPorcine coronary artery smooth muscle cellsCultured vascular smooth muscle cellsArtery smooth muscle cellsCoronary artery smooth muscle cellsVascular smooth muscleMagnitude of stretchStretch-induced reductionAdenylate cyclase activityPotential biochemical mechanismsPerfusion pressureCoronary circulationCycles/minMyogenic responseSmooth muscleMechanical stretchAdenylate cyclasePotential mechanismsEntire time courseUnstretched cellsTime course