2021
Treatment and prevention of viral hepatitis in pregnancy
Dionne-Odom J, Cozzi GD, Franco RA, Njei B, Tita ATN. Treatment and prevention of viral hepatitis in pregnancy. American Journal Of Obstetrics And Gynecology 2021, 226: 335-346. PMID: 34516961, PMCID: PMC8907340, DOI: 10.1016/j.ajog.2021.09.002.Peer-Reviewed Original ResearchConceptsHepatitis BViral hepatitisHepatitis AHepatitis CAntiviral therapyPregnant womenVertical transmissionImmunoglobulin GActive hepatitis BBirth dose vaccineChronic viral hepatitisHigh clinical suspicionBlood-borne transmissionElevated viral loadRisk of acquisitionVertical transmission riskMedical history reviewTenofovir disoproxil fumarateAcquisition of infectionFecal-oral transmissionRoutine prenatal screeningRoute of infectionHerpes simplex virusVaccine seriesCesarean delivery
2019
Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma
Guerra MT, Florentino RM, Franca A, Lima Filho AC, Dos Santos ML, Fonseca RC, Lemos FO, Fonseca MC, Kruglov E, Mennone A, Njei B, Gibson J, Guan F, Cheng YC, Ananthanarayanan M, Gu J, Jiang J, Zhao H, Lima CX, Vidigal PT, Oliveira AG, Nathanson MH, Leite MF. Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma. Gut 2019, 68: 1676. PMID: 31315892, PMCID: PMC7087395, DOI: 10.1136/gutjnl-2018-317811.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsApoptosisCalcium SignalingCarcinogenesisCarcinoma, HepatocellularCell ProliferationCells, CulturedDNA MethylationFemaleGene Expression Regulation, NeoplasticHepatocytesHumansInositol 1,4,5-Trisphosphate ReceptorsLiverLiver NeoplasmsLiver RegenerationMaleMice, KnockoutMiddle AgedSurvival AnalysisConceptsChronic liver diseaseITPR3 expressionLiver cancer cellsLiver diseaseMouse modelFinal common eventCancer cellsSpecimens of patientsIndependent patient cohortsControl liver specimensHuman HCC cellsType 3 InsP3 receptorHuman liver samplesIncreased expression levelCancer deathPatient cohortCommon molecular eventPoor survivalHepatocellular carcinomaLiver specimensNormal liverHCC cellsAbstractTextHCCType 3 isoformRegional and Rural-Urban Differences in the Use of Direct-acting Antiviral Agents for Hepatitis C Virus
Njei B, Esserman D, Krishnan S, Ohl M, Tate JP, Hauser RG, Taddei T, Lim J, Justice AC. Regional and Rural-Urban Differences in the Use of Direct-acting Antiviral Agents for Hepatitis C Virus. Medical Care 2019, 57: 279-285. PMID: 30807449, PMCID: PMC6436819, DOI: 10.1097/mlr.0000000000001071.Peer-Reviewed Original ResearchConceptsDirect-acting antiviral agentsHepatitis C virus infectionVeterans Affairs Healthcare SystemRural-Urban Commuting Area codesCurative HCV treatmentRural-urban designationC virus infectionElectronic health record dataHepatitis C virusPrior treatment experienceLower odds ratioHealth record dataZone improvement plan codeEligible patientsHCV treatmentAntiretroviral medicationsRural-urban residenceLiver diseaseUnadjusted analysesC virusRural-urban differencesOdds ratioMultivariable modelLower incidenceObservational studyImpact of Bariatric Surgery on Outcomes of Patients with Sickle Cell Disease: a Nationwide Inpatient Sample Analysis, 2004–2014
Sharma P, McCarty TR, Yadav S, Ngu JN, Njei B. Impact of Bariatric Surgery on Outcomes of Patients with Sickle Cell Disease: a Nationwide Inpatient Sample Analysis, 2004–2014. Obesity Surgery 2019, 29: 1789-1796. PMID: 30805858, DOI: 10.1007/s11695-019-03780-0.Peer-Reviewed Original ResearchConceptsSickle cell diseaseVaso-occlusive crisisAcute chest syndromeBariatric surgeryIncidence risk ratioChest syndromeMorbid obesityClinical outcomesHospitalization costsCell diseaseUnited States Nationwide Inpatient Sample databaseNationwide Inpatient Sample databaseOutcomes of patientsMulti-organ failureSurgery-related complicationsHigher hospitalization costsUrinary tract infectionWeight loss surgeryDisease-specific treatmentLength of staySickle cell patientsHospital mortalityRespiratory failureThromboembolic eventsConclusionsBariatric surgeryEffects of Endotoxin on Type 3 Inositol 1,4,5‐Trisphosphate Receptor in Human Cholangiocytes
Franca A, Filho A, Guerra MT, Weerachayaphorn J, dos Santos M, Njei B, Robert M, Lima C, Vidigal P, Banales JM, Ananthanarayanan M, Leite MF, Nathanson MH. Effects of Endotoxin on Type 3 Inositol 1,4,5‐Trisphosphate Receptor in Human Cholangiocytes. Hepatology 2019, 69: 817-830. PMID: 30141207, PMCID: PMC6351171, DOI: 10.1002/hep.30228.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Alcoholic hepatitisEffect of endotoxinBile duct cellsNF-κBInhibition of TLR4Human cholangiocytesStimulation of TLR4Duct cellsSevere alcoholic hepatitisCholestasis of sepsisForms of cholestasisNF-κB subunitsP65/p50Trisphosphate receptorReceptor 4Clinical conditionsBicarbonate secretionHepatocellular changesITPR3 expressionCholestasisType 3 inositolLPS receptorAgonist stimulusSepsisEffects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis
Kaplan DE, Serper M, Mehta R, Fox R, John B, Aytaman A, Baytarian M, Hunt K, Albrecht J, Njei B, Taddei TH, Group V. Effects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis. Gastroenterology 2019, 156: 1693-1706.e12. PMID: 30660733, DOI: 10.1053/j.gastro.2019.01.026.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, HepatocellularCholesterolFemaleHeart FailureHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaLiver CirrhosisLiver NeoplasmsMaleMiddle AgedMyocardial InfarctionPropensity ScoreProportional Hazards ModelsRandomized Controlled Trials as TopicRetrospective StudiesStrokeSurvival RateUnited StatesConceptsRetrospective cohort studyStatin exposureLarge national cohortHepatic decompensationStatin useCohort studyHazard ratioNational cohortMultivariable Cox proportional hazards modelsCox proportional hazards modelBaseline total cholesterolPrior statin exposureStatin-naïve subjectsEffect of hypercholesterolemiaVeterans Health AdministrationProportional hazards modelHepatocellular carcinoma developmentDecrease of mortalityRisk-set matchingChild-TurcottePugh classStatin therapyDL increaseTotal cholesterolHepatic functionNational Trends in Use of Opioid Drugs Among Cirrhosis-related Hospitalizations in the United States, 2004 to 2012
McCarty TR, Haque L, Njei B. National Trends in Use of Opioid Drugs Among Cirrhosis-related Hospitalizations in the United States, 2004 to 2012. Journal Of Clinical Gastroenterology 2019, 53: 78-79. PMID: 27984400, DOI: 10.1097/mcg.0000000000000771.Peer-Reviewed Original Research
2018
Cannabis Use Is Associated With Increased Risk of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis
Njei B, Sharma P, McCarty TR, Singh M, Haque L, Aslanian HR, Jamidar P, Muniraj T. Cannabis Use Is Associated With Increased Risk of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis. Pancreas 2018, 47: 1142-1149. PMID: 30134357, DOI: 10.1097/mpa.0000000000001143.Peer-Reviewed Original ResearchConceptsPost-endoscopic retrograde cholangiopancreatography pancreatitisIncidence risk ratioCholangiopancreatography pancreatitisCannabis useRisk of PEPEndoscopic retrograde cholangiopancreatography pancreatitisUS Nationwide Inpatient SampleRate of PEPShorter hospital stayNationwide Inpatient SampleNinth Edition codesImpact of cannabisPoisson regression modelsHospital deathHospital stayIndependent predictorsEdition codesRisk ratioInpatient SampleInternational ClassificationMultivariate analysisPancreatitisPatientsCannabisSignificant increaseImpact of bariatric surgery in patients with HIV infection
Sharma P, McCarty TR, Ngu JN, O'Donnell M, Njei B. Impact of bariatric surgery in patients with HIV infection. AIDS 2018, 32: 1959-1965. PMID: 30157083, PMCID: PMC6126912, DOI: 10.1097/qad.0000000000001915.Peer-Reviewed Original ResearchConceptsBariatric surgeryIncidence risk ratioMorbid obesityRespiratory failureObese patientsRenal failureClinical outcomesUnited States Nationwide Inpatient Sample databaseNationwide Inpatient Sample databaseObese HIV patientsLife-threatening morbidityUrinary tract infectionWeight loss surgeryRelevant clinical outcomesLength of stayRates of obesityHospital mortalityHIV patientsThromboembolic eventsSecondary outcomesTract infectionsHIV infectionPrimary outcomeMultivariable analysisDischarge diagnosis
2017
Impact of Bariatric Surgery on Outcomes of Patients with Inflammatory Bowel Disease: a Nationwide Inpatient Sample Analysis, 2004–2014
Sharma P, McCarty TR, Njei B. Impact of Bariatric Surgery on Outcomes of Patients with Inflammatory Bowel Disease: a Nationwide Inpatient Sample Analysis, 2004–2014. Obesity Surgery 2017, 28: 1015-1024. PMID: 29047047, DOI: 10.1007/s11695-017-2959-0.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBariatric SurgeryDatabases, FactualFemaleHospital CostsHospital MortalityHospitalizationHumansIncidenceInflammatory Bowel DiseasesInpatientsMaleMiddle AgedMorbidityObesity, MorbidPostoperative ComplicationsPrognosisTreatment OutcomeUnited StatesYoung AdultConceptsInflammatory bowel diseaseIncidence risk ratioObese IBD patientsBariatric surgeryMorbid obesityIBD patientsRenal failureBowel diseaseClinical outcomesUnited States National Inpatient Sample (NIS) databaseNational Inpatient Sample databaseOutcomes of patientsLength of stayPaucity of dataHospital mortalityThromboembolic eventsObese patientsSecondary outcomesHospitalized patientsPrimary outcomeMultivariable analysisDischarge diagnosisFistula formationHospitalization costsRisk ratioSurvival after treatment with curative intent for hepatocellular carcinoma among patients with vs without non‐alcoholic fatty liver disease
Wong CR, Njei B, Nguyen MH, Nguyen A, Lim JK. Survival after treatment with curative intent for hepatocellular carcinoma among patients with vs without non‐alcoholic fatty liver disease. Alimentary Pharmacology & Therapeutics 2017, 46: 1061-1069. PMID: 28960360, DOI: 10.1111/apt.14342.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseFatty liver diseaseLarger tumor sizeLiver diseaseHCC etiologyCurative intentNAFLD-HCCCurative treatmentTumor sizeMetastatic HCCCardiovascular diseaseHepatocellular carcinomaDecompensated liver diseaseWorse median survivalAbsence of cirrhosisSignificant survival differenceDiagnosis of HCCLess cirrhosisNAFLD groupMedian survivalWorse survivalFavorable survivalIndependent predictorsLiver cirrhosisHCC groupImpact of bariatric surgery on outcomes of patients with nonalcoholic fatty liver disease: a nationwide inpatient sample analysis, 2004–2012
McCarty TR, Echouffo-Tcheugui JB, Lange A, Haque L, Njei B. Impact of bariatric surgery on outcomes of patients with nonalcoholic fatty liver disease: a nationwide inpatient sample analysis, 2004–2012. Surgery For Obesity And Related Diseases 2017, 14: 74-80. PMID: 29055669, DOI: 10.1016/j.soard.2017.09.511.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseasePrior bariatric surgeryBariatric surgeryFatty liver diseaseIncidence risk ratioNAFLD patientsMorbid obesityRenal failureClinical outcomesLiver diseaseMyocardial infarctionRisk ratioNationwide Inpatient Sample AnalysisNationwide Inpatient Sample databaseObese NAFLD patientsOutcomes of patientsBariatric surgery proceduresMorbidly obese individualsPopulation-based dataHospital mortalityHospital morbidityInpatient mortalitySecondary outcomesHospitalized patientsPrimary outcomeEarly transjugular intrahepatic portosystemic shunt in US patients hospitalized with acute esophageal variceal bleeding
Njei B, McCarty TR, Laine L. Early transjugular intrahepatic portosystemic shunt in US patients hospitalized with acute esophageal variceal bleeding. Journal Of Gastroenterology And Hepatology 2017, 32: 852-858. PMID: 27624167, PMCID: PMC5350067, DOI: 10.1111/jgh.13593.Peer-Reviewed Original ResearchConceptsEarly transjugular intrahepatic portosystemic shuntTransjugular intrahepatic portosystemic shuntAcute esophageal variceal bleedingEsophageal variceal bleedingIntrahepatic portosystemic shuntVariceal bleedingUS patientsPortosystemic shuntNationwide Inpatient Sample databaseHospital mortality rateUS clinical practiceDays of hospitalizationFurther bleedingHospital deathRecurrent bleedingEndoscopic therapyInpatient mortalityPreventive therapySecondary outcomesHepatic encephalopathyPrimary outcomeHigh riskHospital reductionMortality ratePatients
2016
Vanishing Bile Duct Syndrome in Hodgkin’s Lymphoma
Bakhit M, McCarty TR, Park S, Njei B, Cho M, Karagozian R, Liapakis A. Vanishing Bile Duct Syndrome in Hodgkin’s Lymphoma. Journal Of Clinical Gastroenterology 2016, 50: 688. PMID: 27203429, PMCID: PMC4980195, DOI: 10.1097/mcg.0000000000000548.Peer-Reviewed Original ResearchPrevalence of hepatitis delta infection in the United States: National Health and Nutrition Examination Survey, 1999‐2012
Njei B, Do A, Lim JK. Prevalence of hepatitis delta infection in the United States: National Health and Nutrition Examination Survey, 1999‐2012. Hepatology 2016, 64: 681-682. PMID: 26453027, PMCID: PMC4826621, DOI: 10.1002/hep.28279.Peer-Reviewed Original ResearchTrends in esophageal cancer survival in United States adults from 1973 to 2009: A SEER database analysis
Njei B, McCarty TR, Birk JW. Trends in esophageal cancer survival in United States adults from 1973 to 2009: A SEER database analysis. Journal Of Gastroenterology And Hepatology 2016, 31: 1141-1146. PMID: 26749521, PMCID: PMC4885788, DOI: 10.1111/jgh.13289.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAge FactorsAgedCarcinoma, Squamous CellEarly Detection of CancerEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaEsophagectomyFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeoplasm StagingPredictive Value of TestsProportional Hazards ModelsRetrospective StudiesRisk FactorsSEER ProgramSurvival RateTime FactorsTreatment OutcomeUnited StatesConceptsSquamous cell carcinomaEsophageal cancerEsophageal adenocarcinomaMedian survivalBetter long-term survival outcomesLong-term survival outcomesOverall median survivalEnd Results (SEER) databaseProportion of patientsSEER database analysisSignificant survival improvementProportional hazards regressionEsophageal cancer survivalLong-term survivalIndependent mortality factorsLocalized diseaseCurative stageSurgical treatmentSurvival improvementHazards regressionResults databaseSurvival outcomesCell carcinomaTreatment modalitiesCancer survivalSplenic Injury and Hemoperitoneum as a Complication of Colonoscopy: A Case Report and Literature Review.
McCarty TR, Liu A, Njei B. Splenic Injury and Hemoperitoneum as a Complication of Colonoscopy: A Case Report and Literature Review. Connecticut Medicine 2016, 80: 217-21. PMID: 27265925.Peer-Reviewed Original ResearchConceptsSplenic injuryPotential complicationsLife-threatening adverse eventsSplenic artery embolizationLife-threatening complicationsClinical examination findingsComplication of colonoscopyModality of choiceRecent colonoscopyUnderappreciated complicationCardiorespiratory complicationsAdverse eventsArtery embolizationExamination findingsCase reportGeneral internistsTherapeutic modalitiesElicited historyClinical acumenComplicationsColonoscopyInjuryHemoperitoneumFrequent useModalities
2015
Syncytial giant cell hepatitis in a patient with chronic lymphocytic leukemia
Gupta N, Njei B. Syncytial giant cell hepatitis in a patient with chronic lymphocytic leukemia. Journal Of Digestive Diseases 2015, 16: 683-688. PMID: 26147671, PMCID: PMC4824312, DOI: 10.1111/1751-2980.12273.Peer-Reviewed Original ResearchConceptsGiant cell hepatitisChronic lymphocytic leukemiaSyncytial giant cell hepatitisHigh-dose corticosteroidsHistory of chemotherapySuch confounding variablesPediatric populationDrug medicationAutoimmune diseasesLiver enzymesVirus infectionLymphocytic leukemiaHepatitisConfounding variablesPatientsViral particlesDiseaseAdultsSuch casesCorticosteroidsHypogammaglobulinemiaMedicationsChemotherapyMalignancyLeukemiaComparative efficacy of antiviral therapy in preventing vertical transmission of hepatitis B: a network meta‐analysis
Njei B, Gupta N, Ewelukwa O, Ditah I, Foma M, Lim JK. Comparative efficacy of antiviral therapy in preventing vertical transmission of hepatitis B: a network meta‐analysis. Liver International 2015, 36: 634-641. PMID: 26352650, PMCID: PMC4824664, DOI: 10.1111/liv.12959.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsFemaleHepatitis B e AntigensHepatitis B Surface AntigensHepatitis B virusHepatitis B, ChronicHumansInfant, NewbornInfectious Disease Transmission, VerticalNetwork Meta-AnalysisPregnancyPregnancy Complications, InfectiousRandomized Controlled Trials as TopicTelbivudineThymidineViral LoadConceptsHepatitis B virusClinical trialsVertical transmissionSeropositive mothersB virusAntiviral drugsComparative efficacyHepatitis B e antigenEfficacy of tenofovirHepatitis B immunizationIndirect treatment comparisonHigh viral loadHBV infectionIntrauterine transmissionHepatitis BAntiviral therapyB immunizationE antigenThird trimesterViral loadChinese patientsGravid motherAbstractTextComprehensive searchTreatment comparisonsEmerging trends in hepatocellular carcinoma incidence and mortality
Njei B, Rotman Y, Ditah I, Lim JK. Emerging trends in hepatocellular carcinoma incidence and mortality. Hepatology 2015, 61: 191-199. PMID: 25142309, PMCID: PMC4823645, DOI: 10.1002/hep.27388.Peer-Reviewed Original ResearchConceptsIB mortalityHCC incidenceHepatocellular carcinomaIncidence of HCCMultivariable Cox regression analysisOverall median survivalCox regression analysisEnd Results (SEER) dataSignificant survival improvementAge-adjusted incidenceU.S. populationHepatocellular carcinoma incidenceJoinpoint Regression ProgramIncidence-based mortalityRegression analysisSignificant increaseCurative modalityLiver transplantCurative stageMedian survivalSurvival improvementCarcinoma incidenceTumor sizeVascular invasionPrimary tumor