Chronic opioid use is associated with obstructive and spastic disorders in the esophagus
Sanchez MJ, Olivier S, Gediklioglu F, Almeida M, Gaeta M, Nigro M, de la Rosa R, Nguyen M, Lalehzari M, Regala F, Njei B, Deng Y, Ciarleglio M, Masoud A. Chronic opioid use is associated with obstructive and spastic disorders in the esophagus. Neurogastroenterology & Motility 2021, 34: e14233. PMID: 34532898, PMCID: PMC11152085, DOI: 10.1111/nmo.14233.Peer-Reviewed Original ResearchConceptsEsophagogastric junction outflow obstructionDistal esophageal spasmNon-opioid usersAchalasia type IIIIneffective esophageal motilityHigh-resolution manometryDistal latencyOpioid useEsophageal motilityOpioid usersMME groupChronic opioid effectsChronic opioid useDose of opioidsEsophageal motility disordersType IIIElectronic medical recordsManometric abnormalitiesSpastic disordersOpioid effectsOutflow obstructionEsophageal spasmMotility disordersRetrospective studyManometric results