2019
Effects of Endotoxin on Type 3 Inositol 1,4,5‐Trisphosphate Receptor in Human Cholangiocytes
Franca A, Filho A, Guerra MT, Weerachayaphorn J, dos Santos M, Njei B, Robert M, Lima C, Vidigal P, Banales JM, Ananthanarayanan M, Leite MF, Nathanson MH. Effects of Endotoxin on Type 3 Inositol 1,4,5‐Trisphosphate Receptor in Human Cholangiocytes. Hepatology 2019, 69: 817-830. PMID: 30141207, PMCID: PMC6351171, DOI: 10.1002/hep.30228.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Alcoholic hepatitisEffect of endotoxinBile duct cellsNF-κBInhibition of TLR4Human cholangiocytesStimulation of TLR4Duct cellsSevere alcoholic hepatitisCholestasis of sepsisForms of cholestasisNF-κB subunitsP65/p50Trisphosphate receptorReceptor 4Clinical conditionsBicarbonate secretionHepatocellular changesITPR3 expressionCholestasisType 3 inositolLPS receptorAgonist stimulusSepsis
2016
Systematic review with meta‐analysis: endoscopic retrograde cholangiopancreatography‐based modalities for the diagnosis of cholangiocarcinoma in primary sclerosing cholangitis
Njei B, McCarty TR, Varadarajulu S, Navaneethan U. Systematic review with meta‐analysis: endoscopic retrograde cholangiopancreatography‐based modalities for the diagnosis of cholangiocarcinoma in primary sclerosing cholangitis. Alimentary Pharmacology & Therapeutics 2016, 44: 1139-1151. PMID: 27696456, DOI: 10.1111/apt.13817.Peer-Reviewed Original ResearchVanishing Bile Duct Syndrome in Hodgkin’s Lymphoma
Bakhit M, McCarty TR, Park S, Njei B, Cho M, Karagozian R, Liapakis A. Vanishing Bile Duct Syndrome in Hodgkin’s Lymphoma. Journal Of Clinical Gastroenterology 2016, 50: 688. PMID: 27203429, PMCID: PMC4980195, DOI: 10.1097/mcg.0000000000000548.Peer-Reviewed Original Research
2015
Single-operator cholangioscopy and targeted biopsies in the diagnosis of indeterminate biliary strictures: a systematic review
Navaneethan U, Hasan MK, Lourdusamy V, Njei B, Varadarajulu S, Hawes RH. Single-operator cholangioscopy and targeted biopsies in the diagnosis of indeterminate biliary strictures: a systematic review. Gastrointestinal Endoscopy 2015, 82: 608-614.e2. PMID: 26071061, PMCID: PMC4826032, DOI: 10.1016/j.gie.2015.04.030.Peer-Reviewed Original ResearchConceptsMalignant biliary stricturesBiliary stricturesDiagnostic odds ratioIndeterminate biliary stricturesSpyBite biopsiesIntraductal biopsiesPeroral cholangioscopyPooled sensitivitySpyGlass cholangioscopySystematic reviewCholangioscopy-guided biopsyPrevious negative imagingRole of cholangioscopyDiagnosis of CCASingle-operator cholangioscopyTargeted biopsiesEmbase databasesBrush cytologyOdds ratioNegative imagingMAIN OUTCOMEBiopsyCholangioscopyStrictureStandard brushing
2014
Comparative effectiveness of biliary brush cytology and intraductal biopsy for detection of malignant biliary strictures: a systematic review and meta-analysis
Navaneethan U, Njei B, Lourdusamy V, Konjeti R, Vargo JJ, Parsi MA. Comparative effectiveness of biliary brush cytology and intraductal biopsy for detection of malignant biliary strictures: a systematic review and meta-analysis. Gastrointestinal Endoscopy 2014, 81: 168-176. PMID: 25440678, PMCID: PMC4824293, DOI: 10.1016/j.gie.2014.09.017.Peer-Reviewed Original ResearchConceptsMalignant biliary stricturesBiliary stricturesIntraductal biopsiesPooled diagnostic odds ratioDiagnostic odds ratioBrush cytologyOdds ratioComparative effectivenessMalignant-appearing biliary stricturesLow-quality studiesBiliary brush cytologyIndeterminate biliary stricturesReferral centerEmbase databasesEgger's testBiopsyStrictureSystematic reviewPublication biasAnalysis of tissuePooled sensitivityBegg-MazumdarCytologyDiagnostic correlationBrushing