2010
Polycystin-2 Contains an Unpaired EF-hand Motif which May Serve as a Ca2+-Sensitive Regulator of Polycystin-2 Channel Activity
Celic A, Petri E, Hodsdon M, Boggon T, Ehrlich B. Polycystin-2 Contains an Unpaired EF-hand Motif which May Serve as a Ca2+-Sensitive Regulator of Polycystin-2 Channel Activity. Biophysical Journal 2010, 98: 532a-533a. DOI: 10.1016/j.bpj.2009.12.2890.Peer-Reviewed Original Research
2000
Regulation of the Type III InsP3 Receptor by InsP3 and ATP
Hagar R, Ehrlich B. Regulation of the Type III InsP3 Receptor by InsP3 and ATP. Biophysical Journal 2000, 79: 271-278. PMID: 10866953, PMCID: PMC1300931, DOI: 10.1016/s0006-3495(00)76289-8.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAllosteric RegulationAnimalsBinding, CompetitiveCalcium ChannelsDose-Response Relationship, DrugEndoplasmic ReticulumInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsInsulinomaMicrosomesProtein IsoformsRatsReceptors, Cytoplasmic and NuclearSubstrate SpecificityTumor Cells, CulturedConceptsType IIIChannel activityIntracellular calciumMaximal channel activityATP concentrationProlonged stimulationDependent inhibitionAllosteric modulationInsP3 receptorEnhanced channel activityType IOpen probabilityOpen timeReceptorsHigh ATP concentrationsHigh levelsATPLow ATP concentrationsIsoformsActivityReversible Block of the Calcium Release Channel/Ryanodine Receptor by Protamine, a Heparin Antidote
Koulen P, Ehrlich B. Reversible Block of the Calcium Release Channel/Ryanodine Receptor by Protamine, a Heparin Antidote. Molecular Biology Of The Cell 2000, 11: 2213-2219. PMID: 10888663, PMCID: PMC14914, DOI: 10.1091/mbc.11.7.2213.Peer-Reviewed Original ResearchConceptsCalcium release channelRyanodine receptorChannel activityIntracellular calcium releaseRelease channelRyanodine receptor activityReceptor type 1Application of protamineMechanism of actionChannel/ryanodine receptorCalcium release channel/ryanodine receptorRelease channel/ryanodine receptorBulk calcium concentrationAddition of heparinRyanodine receptor type 1Single-channel activityReceptor activityCalcium releaseType 1Muscle cellsCalcium concentrationSkeletal muscleHeparin antidoteReversible blockProtamine sulfate
1993
ATP modulates the function of inositol 1,4,5-trisphosphate-gated channels at two sites
Bezprozvanny I, Ehrlich B. ATP modulates the function of inositol 1,4,5-trisphosphate-gated channels at two sites. Neuron 1993, 10: 1175-1184. PMID: 7686381, DOI: 10.1016/0896-6273(93)90065-y.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCalciumCalcium ChannelsCerebellumDogsEndoplasmic ReticulumInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsIon Channel GatingIon ChannelsKineticsLipid BilayersMathematicsMicrosomesModels, NeurologicalReceptors, Cell SurfaceReceptors, Cytoplasmic and NuclearSignal TransductionConceptsPresence of IP3Effect of ATPTrisphosphate-gated channelsIntracellular Ca2Average durationAllosteric modulationSingle-channel levelFunction of inositolIP3 receptorChannel activityCell viabilityReceptorsTrisphosphate receptorIP3Channel openingPermeable channelsCa2ATPInositolAddition of ATPNonhydrolyzable ATP analogChannel conductanceChannel incorporation