2022
Gene expressions and their significance in organoid cultures obtained from breast cancer patient-derived biopsies
Pranav P, Palaniyandi T, Baskar G, Ravi M, Rajendran B, Sivaji A, Ranganathan M. Gene expressions and their significance in organoid cultures obtained from breast cancer patient-derived biopsies. Acta Histochemica 2022, 124: 151910. PMID: 35667159, DOI: 10.1016/j.acthis.2022.151910.Peer-Reviewed Original ResearchConceptsBreast cancerOrganoid culturesGene expression changesPatient-derived biopsiesBreast cancer biopsiesExpression of ErbB2Progesterone receptor geneCancer cell linesExpression changesSuch cancersPatient biopsiesCancer biopsiesSolid tumorsBiopsyMalignant cellsCancerGene expressionMagnitude of expressionHuman cancersCancer therapyReceptor geneCell linesSuch organoidsCancer researchFunctional physiology
2020
NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
Miao K, Lei J, Valecha M, Zhang A, Xu J, Wang L, Lyu X, Chen S, Miao Z, Zhang X, Su S, Shao F, Rajendran B, Bao J, Zeng J, Sun H, Chen P, Tan K, Chen Q, Wong K, Xu X, Deng C. NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation. Nature Communications 2020, 11: 3256. PMID: 32591500, PMCID: PMC7320176, DOI: 10.1038/s41467-020-16936-9.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAnimalsAtaxia Telangiectasia Mutated ProteinsBRCA1 ProteinCarcinogenesisCell DeathCell Line, TumorCheckpoint Kinase 1Disease ProgressionDNA Transposable ElementsEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansMice, KnockoutMitosisMutationReceptor, Notch1Signal TransductionTriple Negative Breast NeoplasmsConceptsTriple-negative breast cancerEpithelial-mesenchymal transitionHuman breast cancer tissuesBRCA1 mutation carriersBreast cancer tissuesBRCA1-deficient miceActivation of Notch1Breast cancer formationRefractory diseaseForm of Notch1Breast cancerMutation carriersHigh riskCancer tissuesClinical optionG2/M cell cycle checkpointFatal diseaseCell cycle checkpointsM cell cycle checkpointNotch1 activationBRCA1 deficiencyPhosphorylation of ATRNotch1Cancer formationCycle checkpoints
2017
Characterization of potential driver mutations involved in human breast cancer by computational approaches
Rajendran B, Deng C. Characterization of potential driver mutations involved in human breast cancer by computational approaches. Oncotarget 2017, 5: 50252-50272. PMID: 28477017, PMCID: PMC5564847, DOI: 10.18632/oncotarget.17225.Peer-Reviewed Original ResearchConceptsBreast cancerHuman breast cancerBreast cancer initiationForms of cancerPotential driver mutationsLethal cancersBreast tumorigenesisCancerDriver mutationsTumor initiationGenetic mutationsCancer initiationDriver genesPathway analysisProgressionMutation genesCellular regulatory pathwaysCandidate driversRegulatory pathwaysMetastasisCancer driversInitiation