comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis
Rajendran B, Deng C. comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis. Oncotarget 2017, 5: 102263-102276. PMID: 29254242, PMCID: PMC5731952, DOI: 10.18632/oncotarget.20404.Peer-Reviewed Original ResearchCopy number alterationsBreast tumorigenesisNumber alterationsGenetic network analysisPrognostic molecular signaturesCancer-associated genesCellular functionsOBSCN geneMultifunctional proteinBreast cancer progressionMyofibril organizationClinical breast cancer samplesGene expressionIntegrative analysisFunctional mutationsDownstream pathwaysExpression dataGenesCell adhesionMolecular signaturesCancer progressionGene methylationDirect roleTumorigenesisObscurinCharacterization of potential driver mutations involved in human breast cancer by computational approaches
Rajendran B, Deng C. Characterization of potential driver mutations involved in human breast cancer by computational approaches. Oncotarget 2017, 5: 50252-50272. PMID: 28477017, PMCID: PMC5564847, DOI: 10.18632/oncotarget.17225.Peer-Reviewed Original ResearchConceptsBreast cancerHuman breast cancerBreast cancer initiationForms of cancerPotential driver mutationsLethal cancersBreast tumorigenesisCancerDriver mutationsTumor initiationGenetic mutationsCancer initiationDriver genesPathway analysisProgressionMutation genesCellular regulatory pathwaysCandidate driversRegulatory pathwaysMetastasisCancer driversInitiation