Childhood adversity and DNA methylation of genes involved in the hypothalamus–pituitary–adrenal axis and immune system: Whole-genome and candidate-gene associations
Bick J, Naumova O, Hunter S, Barbot B, Lee M, Luthar SS, Raefski A, Grigorenko EL. Childhood adversity and DNA methylation of genes involved in the hypothalamus–pituitary–adrenal axis and immune system: Whole-genome and candidate-gene associations. Development And Psychopathology 2012, 24: 1417-1425. PMID: 23062307, PMCID: PMC3755948, DOI: 10.1017/s0954579412000806.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChildChild AbuseDNA MethylationEpigenesis, GeneticGenetic Association StudiesGenome-Wide Association StudyHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemStress, PsychologicalConceptsDNA methylation profilesMethylation profilesCandidate gene associationsDNA methylationEpigenetic alterationsMolecular geneticsPhysiological pathwaysKey biological systemsImmune systemBiological systemsGenomeGenesMethylationGeneticsAlterationsPathwayHumansAdrenal axisTranslational researchFuture research effortsImportant future directionsDevelopmental trajectories