2018
Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier.
Jing W, Jabbari B, Vaziri ND. Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier. American Journal Of Translational Research 2018, 10: 2137-2147. PMID: 30093950, PMCID: PMC6079125.Peer-Reviewed Original ResearchImpaired blood-brain barrierBlood-brain barrierCerebral cortexBrain barrierNF-κBBody weightChronic kidney disease (CKD) resultsInducible NO synthase isoformCentral nervous system disordersOxidative stressElevated serum ureaPro-inflammatory moleculesEndothelial junctional complexesNuclear translocationReduced body weightMale Sprague-DawleyTissue oxidative stressNervous system disordersNO synthase (NOS) isoformsCKD groupCKD ratsFibrosis mediatorsWestern blot analysisRenal functionArterial pressure
2017
The nature, consequences, and management of neurological disorders in chronic kidney disease
Jabbari B, Vaziri ND. The nature, consequences, and management of neurological disorders in chronic kidney disease. Hemodialysis International 2017, 22: 150-160. PMID: 28799704, DOI: 10.1111/hdi.12587.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseNeurological disordersNeurological symptomsKidney diseaseImpaired blood-brain barrierDiffuse white matter diseasePeripheral neurological symptomsRestless legs syndromeCentral neurological symptomsBlood-brain barrierWhite matter diseaseCentral nervous systemReflex myoclonusNeurological complicationsPeripheral neuropathyBrain edemaCortical myoclonusHemodynamic disordersLegs syndromePeripheral originBasal gangliaBrain barrierSubcortical lesionsMovement disordersSubcortical pathology