2018
Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier.
Jing W, Jabbari B, Vaziri ND. Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier. American Journal Of Translational Research 2018, 10: 2137-2147. PMID: 30093950, PMCID: PMC6079125.Peer-Reviewed Original ResearchImpaired blood-brain barrierBlood-brain barrierCerebral cortexBrain barrierNF-κBBody weightChronic kidney disease (CKD) resultsInducible NO synthase isoformCentral nervous system disordersOxidative stressElevated serum ureaPro-inflammatory moleculesEndothelial junctional complexesNuclear translocationReduced body weightMale Sprague-DawleyTissue oxidative stressNervous system disordersNO synthase (NOS) isoformsCKD groupCKD ratsFibrosis mediatorsWestern blot analysisRenal functionArterial pressure
2008
Regional Expression of NAD(P)H Oxidase and Superoxide Dismutase in the Brain of Rats with Neurogenic Hypertension
Bai Y, Jabbari B, Ye S, Campese VM, Vaziri ND. Regional Expression of NAD(P)H Oxidase and Superoxide Dismutase in the Brain of Rats with Neurogenic Hypertension. American Journal Of Nephrology 2008, 29: 483-492. PMID: 19047792, PMCID: PMC2821947, DOI: 10.1159/000178817.Peer-Reviewed Original ResearchConceptsKidney cortexInjection of phenolCentral noradrenergic activityBrain of ratsRats 4 weeksAssociated hypertensionChronic hypertensionNeurogenic hypertensionArterial pressureBlood pressureNoradrenergic activityNoradrenergic controlLateral ventricleHypertensionRole of superoxideSingle injectionMaladaptive changesPathway activationReactive oxygen speciesRatsUpregulationOxidase subunitsBrainSuperoxide dismutaseCortex
2006
Regional expression of NO synthase, NAD(P)H oxidase and superoxide dismutase in the rat brain
Campese VM, Sindhu RK, Ye S, Bai Y, Vaziri ND, Jabbari B. Regional expression of NO synthase, NAD(P)H oxidase and superoxide dismutase in the rat brain. Brain Research 2006, 1134: 27-32. PMID: 17196179, DOI: 10.1016/j.brainres.2006.11.067.Peer-Reviewed Original ResearchConceptsEndothelial NO synthaseSoluble guanylate cyclaseNeuronal NOSNitric oxideGlutathione peroxidaseNO synthaseRat brainSuperoxide dismutaseActivation of NOSNormal rat brainImportance of NOArterial pressureCytoplasmic superoxide dismutaseSympathetic activityCerebral circulationBrain perfusionCentral regulationBrain functionGuanylate cyclaseNO receptorMedullaNOSPonsAntioxidant enzymesRelative expression