Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading
Seidel T, Navankasattusas S, Ahmad A, Diakos N, Xu W, Tristani-Firouzi M, Bonios M, Taleb I, Li D, Selzman C, Drakos S, Sachse F. Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading. Circulation 2017, 135: 1632-1645. PMID: 28073805, PMCID: PMC5404964, DOI: 10.1161/circulationaha.116.024470.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiopsyCase-Control StudiesEchocardiographyExcitation Contraction CouplingFemaleHeart FailureHeart-Assist DevicesHumansImage Processing, Computer-AssistedMaleMicroscopy, ConfocalMiddle AgedMyocardial ContractionMyocytes, CardiacProspective StudiesProsthesis DesignRecovery of FunctionRyanodine Receptor Calcium Release ChannelTime FactorsTreatment OutcomeVentricular Function, LeftVentricular RemodelingConceptsLeft ventricular assist deviceChronic heart failureHeart failureExcitation-contraction couplingCardiac recoveryMechanical unloadingLVAD implantationEjection fractionFunctional recoveryHF myocytesImplantation of LVADHallmark of HFHuman end-stage heart failureLeft ventricular ejection fractionEnd-stage heart failureTransverse tubular systemEnd-stage human heart failureEjection fraction increaseIsolated human cardiomyocytesVentricular ejection fractionSubgroup of patientsVolume/length ratioHuman heart failureFunctional cardiac recoveryVentricular assist device