Location and function of transient receptor potential canonical channel 1 in ventricular myocytes
Hu Q, Ahmad A, Seidel T, Hunter C, Streiff M, Nikolova L, Spitzer K, Sachse F. Location and function of transient receptor potential canonical channel 1 in ventricular myocytes. Journal Of Molecular And Cellular Cardiology 2020, 139: 113-123. PMID: 31982426, PMCID: PMC7085981, DOI: 10.1016/j.yjmcc.2020.01.008.Peer-Reviewed Original ResearchConceptsNeonatal rat ventricular myocytesRabbit ventricular myocytesVentricular myocytesSarcoplasmic reticulumChannel blocker SKF-96365TRPC1 overexpressionTransient receptor potential canonical channel 1Physiological pacing ratesTRPC1 channelsAdult rabbit ventricular myocytesRole of TRPC1Rat ventricular myocytesSarco/endoplasmic reticulum CaTransient receptor potentialMammalian ventricular myocytesIsolated rabbit cardiomyocytesEndoplasmic reticulum CaSKF-96365Free solutionCardiac hypertrophyPacing rateAction potentialsTRPC channelsTransverse tubular systemReticulum Ca