2004
Regulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro
Berkkanoglu M, Guzeloglu-Kayisli O, Kayisli U, Selam B, Arici A. Regulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro. Molecular Human Reproduction 2004, 10: 393-398. PMID: 15073283, DOI: 10.1093/molehr/gah060.Peer-Reviewed Original ResearchConceptsStromal cell survivalCell survivalStromal cellsVascular endothelial growth factorEndometrial stromal cellsPotent mitogenic cytokineFasL expressionGrowth factorRegulation of FasLApoptotic signalingTranslation levelsFas ligand expressionWestern blot analysisEndothelial growth factorFas receptorFasL levelsBlot analysisFas ligandExpression of FasLConcentration-dependent mannerMitogenic cytokinesEffects of VEGFRegulationExpressionParacrine manner
2001
Estradiol regulates monocyte chemotactic protein-1 in human coronary artery smooth muscle cells: a mechanism for its antiatherogenic effect
Seli E, Selam B, Mor G, Kayisli U, Pehlivan T, Arici A. Estradiol regulates monocyte chemotactic protein-1 in human coronary artery smooth muscle cells: a mechanism for its antiatherogenic effect. Menopause The Journal Of The North American Menopause Society 2001, 8: 296-301. PMID: 11449089, DOI: 10.1097/00042192-200107000-00013.Peer-Reviewed Original ResearchConceptsHuman coronary artery smooth muscle cellsCoronary artery smooth muscle cellsArtery smooth muscle cellsMonocyte chemotactic protein-1Smooth muscle cellsChemotactic protein-1Recruitment of macrophagesMCP-1 expressionMCP-1 proteinMuscle cellsProtective effectProtein 1Arterial wallSelective estrogen receptor modulatorsCoronary smooth muscle cellsMCP-1 protein productionEstrogen's protective effectPhenol red-free mediumCharcoal-stripped calf serumProtein productionEstrogen receptor modulatorsPathogenesis of atherosclerosisReverse transcriptase-polymerase chain reactionNorthern blotLow-density lipoprotein
2000
Hyperinsulinism and Its Interaction With Hyperandrogenism in Polycystic Ovary Syndrome
Sozen I, Arici A. Hyperinsulinism and Its Interaction With Hyperandrogenism in Polycystic Ovary Syndrome. Obstetrical & Gynecological Survey 2000, 55: 321-328. PMID: 10804539, DOI: 10.1097/00006254-200005000-00026.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeInsulin resistanceOvary syndromeGenetic predispositionCommon endocrine disorderInsulin receptorRole of insulinHyperinsulinemic hyperandrogenismEndocrine disordersReproductive ageHyperandrogenismIndependent factorsHyperinsulinismPostbinding defectComputerized searchSyndromeSignificant subgroupReceptor signal transductionEnglish literatureRelevant studiesVicious cycleReceptorsInsulin genePredispositionPossible mechanismLeukocytes in ovarian function
Bukulmez O, Arici A. Leukocytes in ovarian function. Human Reproduction Update 2000, 6: 1-15. PMID: 10711825, DOI: 10.1093/humupd/6.1.1.Peer-Reviewed Original ResearchConceptsOvarian functionRelease of chemokinesAcute inflammatory reactionCorpus luteum formationConnective tissue elementsImmune cellsGonadal functionInflammatory reactionCell adhesion moleculeLocal secretionOvarian disordersLeukocyte migrationNumerous cytokinesImmune systemSoluble factorsFollicle wallProgressive infiltrationAdhesion moleculesLeukocytesThecal fibroblastsTissue elementsCytokinesCellsActual ruptureChemokines
1999
Interleukin-8 expression in endometrial stromal cells is regulated by integrin-dependent cell adhesion
Garcia-Velasco J, Arici A. Interleukin-8 expression in endometrial stromal cells is regulated by integrin-dependent cell adhesion. Molecular Human Reproduction 1999, 5: 1135-1140. PMID: 10587368, DOI: 10.1093/molehr/5.12.1135.Peer-Reviewed Original ResearchTumor Necrosis Factor-α Stimulates Proliferation of Rat Ovarian Theca-Interstitial Cells1
Spaczynski R, Arici A, Duleba A. Tumor Necrosis Factor-α Stimulates Proliferation of Rat Ovarian Theca-Interstitial Cells1. Biology Of Reproduction 1999, 61: 993-998. PMID: 10491635, DOI: 10.1095/biolreprod61.4.993.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeTNF-alphaTheca-interstitial cellsOvarian theca-interstitial cellsRat Ovarian Theca-Interstitial CellsInsulin-like growth factor ISerum TNF-alphaGrowth factor II cell proliferationDose-dependent fashionCytometry DNA analysisEffect of insulinOvary syndromeOvarian functionRat TTumor necrosisPathophysiologic roleTotal cell countProliferative indexCell countPotent modulatorFactor IIncorporation assayIGFInsulinInterleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin
Garcia-Velasco J, Arici A. Interleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin. Fertility And Sterility 1999, 72: 336-340. PMID: 10439007, DOI: 10.1016/s0015-0282(99)00223-x.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsInterleukin-8IL-8 monoclonal antibodyStromal cellsMonoclonal antibodiesBenign gynecologic surgeryPathogenesis of endometriosisConcentration-dependent increaseConcentration-dependent mannerEndometrial implantsEndometrial diseaseGynecologic surgeryMAIN OUTCOMEAntibodiesStromal cell adhesionAdhesion assaysAcademic research laboratoriesCellsCell adhesionEndometriosisSurgeryPathogenesisDiseaseWomenRegulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Integrin-Dependent Cell Adhesion1
Garcia-Velasco J, Seli E, Arici A. Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Integrin-Dependent Cell Adhesion1. Biology Of Reproduction 1999, 61: 548-552. PMID: 10411539, DOI: 10.1095/biolreprod61.2.548.Peer-Reviewed Original ResearchConceptsCell adhesionExtracellular matrix connectionsActin cytoskeletonMCP-1 regulationGene expressionIntegrin activationECM substratesProtein secretionStromal cell adhesionCytochalasin DCell typesMCP-1 gene expressionNovel mechanismHuman endometrial stromal cellsMonocyte chemotactic protein-1 expressionProtein levelsIntegrinsProtein-1 expressionAdhesion matrixRegulationExpressionStromal cellsESC adhesionEndometrial stromal cellsCollagen IVImmunology of endometriosis
Senturk L, Arici A. Immunology of endometriosis. Journal Of Reproductive Immunology 1999, 43: 67-83. PMID: 10392782, DOI: 10.1016/s0165-0378(98)00079-5.Peer-Reviewed Original ResearchHOX gene expression is altered in the endometrium of women with endometriosis
Taylor H, Bagot C, Kardana A, Olive D, Arici A. HOX gene expression is altered in the endometrium of women with endometriosis. Human Reproduction 1999, 14: 1328-1331. PMID: 10325287, DOI: 10.1093/humrep/14.5.1328.Peer-Reviewed Original ResearchProliferation and Differentiation of Rat Theca-Interstitial Cells: Comparison of Effects Induced by Platelet-Derived Growth Factor and Insulin-Like Growth Factor-I1
Duleba A, Spaczynski R, Arici A, Carbone R, Behrman H. Proliferation and Differentiation of Rat Theca-Interstitial Cells: Comparison of Effects Induced by Platelet-Derived Growth Factor and Insulin-Like Growth Factor-I1. Biology Of Reproduction 1999, 60: 546-550. PMID: 10026097, DOI: 10.1095/biolreprod60.3.546.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factorInsulin-like growth factorTheca-interstitial cellsGrowth factorRat theca-interstitial cellsImmature Sprague-Dawley ratsI cellsSprague-Dawley ratsDose-dependent increaseDNA synthesisComparison of effectsActive cellsIGFFlow cytometryThymidine incorporationStimulatory effectProliferationCell countingCytometryCellsDehydrogenase activityTotal numberIndividual subpopulationsProportionDividing cells
1998
The effect of monocyte chemotactic protein 1 in intraperitoneal adhesion formation in a mouse model
Zeyneloglu H, Seli E, Senturk L, Gutierrez L, Olive D, Arici A. The effect of monocyte chemotactic protein 1 in intraperitoneal adhesion formation in a mouse model. American Journal Of Obstetrics And Gynecology 1998, 179: 438-443. PMID: 9731850, DOI: 10.1016/s0002-9378(98)70376-x.Peer-Reviewed Original ResearchBasic Fibroblast Growth Factor: Peritoneal and Follicular Fluid Levels and its Effect on Early Embryonic Development
Seli E, Zeyneloglu H, Senturk L, Bahtiyar O, Olive D, Arici A. Basic Fibroblast Growth Factor: Peritoneal and Follicular Fluid Levels and its Effect on Early Embryonic Development. Fertility And Sterility 1998, 69: 1145-1148. PMID: 9627307, DOI: 10.1016/s0015-0282(98)00074-0.Peer-Reviewed Original ResearchConceptsBasic fibroblast growth factorFibroblast growth factorPeritoneal fluidFollicular fluidBasic FGF levelsFollicular fluid levelsPresence of endometriosisFGF levelsBlastocyst formationException of ageOvulation inductionProspective studyMenstrual cycleMAIN OUTCOMEFluid levelsEndometriosisMurine preimplantation embryonic developmentGrowth factorFGF concentrationsPreimplantation embryonic developmentWomenTwo-cell murine embryosPreimplantation embryosEmbryonic developmentReproductive parametersInterleukin-8 in the Human Endometrium1
Arici A, Seli E, Senturk L, Gutierrez L, Oral E, Taylor H. Interleukin-8 in the Human Endometrium1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 1783-1787. PMID: 9589693, DOI: 10.1210/jcem.83.5.4754.Peer-Reviewed Original ResearchConceptsIL-8 messenger ribonucleic acidInterleukin-8Menstrual cycleMessenger ribonucleic acidHuman endometriumMenstrual historyT cell chemotactic activityIL-8 mRNA levelsWoman's menstrual historyImmunoreactive IL-8IL-8 antibodyIL-8 expressionIL-8 proteinEndometrial biopsyEndometrial diseaseEndometrial tissueSex hormonesHuman uterusSurface epitheliumChemotactic activityEndometriumFrozen sectionsStromal cellsLate secretoryGlandular cellsLeukemia Inhibitory Factor in Human Reproduction
Senturk L, Arici A. Leukemia Inhibitory Factor in Human Reproduction. American Journal Of Reproductive Immunology 1998, 39: 144-151. PMID: 9506212, DOI: 10.1111/j.1600-0897.1998.tb00346.x.Peer-Reviewed Original ResearchConceptsLeukemia inhibitory factorFallopian tubeMenstrual cycleHuman endometriumMenstrual cycle-dependent mannerInhibitory factorRole of LIFEffects of LIFHuman reproductionEndometrial LIF expressionMyeloid leukemic cell linesTime of implantationTime of ovulationLIF levelsOvulatory eventsLIF expressionInterleukin-6 familyStromal cell culturesEndometrial tissueInflammatory cytokinesLeukemic cell linesPeripheral neuronsPleiotropic cytokineSuccessful implantationOvarian follicles
1997
ENVIRONMENTAL TOXINS AND ENDOMETRIOSIS
Zeyneloglu H, Arici A, Olive D. ENVIRONMENTAL TOXINS AND ENDOMETRIOSIS. Obstetrics And Gynecology Clinics Of North America 1997, 24: 307-329. PMID: 9163769, DOI: 10.1016/s0889-8545(05)70306-5.Peer-Reviewed Original Research
1996
The peritoneal environment in endometriosis
Oral E, Olive D, Arici A. The peritoneal environment in endometriosis. Human Reproduction Update 1996, 2: 385-398. PMID: 15717438, DOI: 10.1093/humupd/2.5.385.Peer-Reviewed Original ResearchConceptsPeritoneal fluidPeritoneal environmentPF of womenEtiology of endometriosisMonocytes/macrophagesSpermatozoon-oocyte interactionEndometriotic implantsEndometrial fragmentsPeritoneal factorsPeritoneal endometriosisRetrograde menstruationIL-8MCP-1Postimplantation survivalChemoattractant cytokinesMast cellsEndometriosisImmune systemMesothelial cellsCytokinesGrowth factorOvum captureMacrophagesEtiologyCell types