2008
Regulation and activation of ezrin protein in endometriosis
Ornek T, Fadiel A, Tan O, Naftolin F, Arici A. Regulation and activation of ezrin protein in endometriosis. Human Reproduction 2008, 23: 2104-2112. PMID: 18552365, DOI: 10.1093/humrep/den215.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsEctopic endometrial tissuePathogenesis of endometriosisWestern blot analysisEndometrial tissueNormal endometriumEctopic endometrial stromal cellsNormal endometrial stromal cellsEctopic endometrial tissue samplesEndometrial tissue samplesEzrin proteinMembrane invasionBlot analysisExpression of ezrinEndometriosisStromal cellsEutopicPotential markerTissue samplesWomenInvasive characteristicsCell invasionEctopic sitesEndometriumInvasive potential
2004
Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis
Luk J, Seval Y, Kayisli UA, Ulukus M, Ulukus CE, Arici A. Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 1805-1811. PMID: 15613411, DOI: 10.1210/jc.2004-1813.Peer-Reviewed Original ResearchConceptsHuman endometrial endothelial cellsIL-8 mRNAEndometrial endothelial cellsIL-8 expressionSex steroidsEndothelial cellsEutopic endometriumCultured human endometrial endothelial cellsIL-8 immunoreactivityEffects of estradiolEutopic endometrial tissuesPathogenesis of endometriosisInterleukin-8 expressionMenstrual cycle phaseEndothelium-specific markersEndometriosis implantsInflammatory basisCytokine levelsEndometriotic implantsInflammatory mediatorsChemokine expressionEndometrial tissueInflammatory aspectsIL-8Endometriosis
2001
Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1
Selam B, Kayisli U, Mulayim N, Arici A. Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1. Biology Of Reproduction 2001, 65: 979-985. PMID: 11566716, DOI: 10.1095/biolreprod65.4.979.Peer-Reviewed Original ResearchConceptsFasL expressionSteroid hormonesEndometrial cellsHuman endometriumMenstrual cycle-dependent expressionGlandular cellsOvarian steroid hormonesSex steroid hormonesEndometrial glandular cellsLate proliferative phaseStrong FasL expressionFas ligand expressionFasL mRNA expressionReverse transcription-polymerase chain reaction analysisTranscription-polymerase chain reaction analysisFasL protein expressionMaternal immunotoleranceWestern blot analysisInteraction of FasLFasL immunoreactivityImplantation windowMenstrual cycleHuman Endometrium1Secretory phaseChain reaction analysisExpression of aminopeptidase N in human endometrium and regulation of its activity by estrogen
Seli E, Senturk L, Bahtiyar O, Kayisli U, Arici A. Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen. Fertility And Sterility 2001, 75: 1172-1176. PMID: 11384645, DOI: 10.1016/s0015-0282(01)01779-4.Peer-Reviewed Original ResearchConceptsExpression of APNEarly proliferative phaseMenstrual cycleInterleukin-8Human endometriumProliferative phaseCultured endometrial stromal cellsEndometrial stromal cell culturesEndometrial stromal cellsUniversity Medical CenterPolymorphonuclear leukocyte chemotaxisAPN activityAminopeptidase NConcentration-dependent mannerEndometrial pathologyEndometrial stromaProspective studyStromal cell culturesEndometrial sectionsAPN antibodyMedical CenterMAIN OUTCOMESex steroidsSecretory phaseEndometriumInterleukin-8 in the Human Fallopian Tube
Palter S, Mulayim N, Senturk L, Arici A. Interleukin-8 in the Human Fallopian Tube. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 2660-2667. PMID: 11397869, DOI: 10.1210/jcem.86.6.7584.Peer-Reviewed Original ResearchConceptsHuman fallopian tubeInterleukin-8Fallopian tubeReceptor AIL-8 receptor AEnzyme aminopeptidase NLocal regulatory factorsEpithelial IL-8Gynecological surgical proceduresTubal physiologyTubal epitheliumTubal segmentsSurgical proceduresProximal tubeSystemic effectsBenign conditionsStromal tissueAminopeptidase NCiliated cellsEpithelial cellsEpitheliumImmunohistochemistryFunctional epitheliumSimilar patternRegulatory factorsInterleukin 8 production and interleukin 8 receptor expression in human myometrium and leiomyoma
Senturk L, Sozen I, Gutierrez L, Arici A. Interleukin 8 production and interleukin 8 receptor expression in human myometrium and leiomyoma. American Journal Of Obstetrics And Gynecology 2001, 184: 559-566. PMID: 11262453, DOI: 10.1067/mob.2001.111160.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, NorthernCell DivisionDose-Response Relationship, DrugEnzyme-Linked Immunosorbent AssayFemaleGonadotropin-Releasing HormoneHumansImmunohistochemistryInterleukin-1Interleukin-8KineticsLeiomyomaMyometriumReceptors, Interleukin-8ARNA, MessengerTumor Cells, CulturedTumor Necrosis Factor-alphaUterine NeoplasmsConceptsInterleukin-8 productionTumor necrosis factor alphaNecrosis factor alphaInterleukin-8Factor alphaInterleukin-1alphaMyometrial cellsCell proliferationInterleukin-8 receptor expressionGonadotropin-releasing hormone agonistType APotent chemoattractant cytokinesDose-dependent increaseMyometrial cell proliferationMessenger ribonucleic acid expressionDose-dependent inhibitionEnzyme-linked immunosorbentRibonucleic acid expressionLeiomyomatous tissueLeiomyomatous uterusHormone agonistHuman myometriumReceptor expressionChemoattractant cytokinesMyometrial tissue
1998
Fas‐Fas Ligand System‐Induced Apoptosis in Human Placenta and Gestational Trophoblastic Disease
Mor G, Gutierrez L, Eliza M, Kahyaoglu F, Arici A. Fas‐Fas Ligand System‐Induced Apoptosis in Human Placenta and Gestational Trophoblastic Disease. American Journal Of Reproductive Immunology 1998, 40: 89-94. PMID: 9764350, DOI: 10.1111/j.1600-0897.1998.tb00396.x.Peer-Reviewed Original ResearchConceptsGestational trophoblastic diseaseTrophoblastic diseaseFasL expressionImmunobiology of pregnancyMaternal immune responseMaternal immune toleranceMaternal-fetal interfaceReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionNick-end labeling assayFas ligand expressionEnd-labeling assayPaternal alloantigensPathologic placentasImmune toleranceFetal antigensT cellsFas-FasLImmune responseNormal placentaLigand expressionPlacentaHuman placentaParaffin sectionsPathologic statesThe effect of monocyte chemotactic protein 1 in intraperitoneal adhesion formation in a mouse model
Zeyneloglu H, Seli E, Senturk L, Gutierrez L, Olive D, Arici A. The effect of monocyte chemotactic protein 1 in intraperitoneal adhesion formation in a mouse model. American Journal Of Obstetrics And Gynecology 1998, 179: 438-443. PMID: 9731850, DOI: 10.1016/s0002-9378(98)70376-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChemokine CCL2ImmunohistochemistryMiceMice, Inbred BALB CPeritoneal DiseasesRNA, MessengerTissue AdhesionsInterleukin-8 in the Human Endometrium1
Arici A, Seli E, Senturk L, Gutierrez L, Oral E, Taylor H. Interleukin-8 in the Human Endometrium1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 1783-1787. PMID: 9589693, DOI: 10.1210/jcem.83.5.4754.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, NorthernEndometriumEpitheliumFemaleFrozen SectionsHumansHysterectomyImmunohistochemistryInterleukin-8Menstrual CycleMiceRNA, MessengerConceptsIL-8 messenger ribonucleic acidInterleukin-8Menstrual cycleMessenger ribonucleic acidHuman endometriumMenstrual historyT cell chemotactic activityIL-8 mRNA levelsWoman's menstrual historyImmunoreactive IL-8IL-8 antibodyIL-8 expressionIL-8 proteinEndometrial biopsyEndometrial diseaseEndometrial tissueSex hormonesHuman uterusSurface epitheliumChemotactic activityEndometriumFrozen sectionsStromal cellsLate secretoryGlandular cells