2004
Phyto-oestrogens and the endometrium
Arici A, Bukulmez O. Phyto-oestrogens and the endometrium. The Lancet 2004, 364: 2081-2082. PMID: 15589297, DOI: 10.1016/s0140-6736(04)17565-x.Peer-Reviewed Original Research
2002
Structural Differentiation of Human Uterine Luminal and Glandular Epithelium during Early Pregnancy: An Ultrastructural and Immunohistochemical Study
Demir R, Kayisli U, Celik-Ozenci C, Korgun E, Demir-Weusten A, Arici A. Structural Differentiation of Human Uterine Luminal and Glandular Epithelium during Early Pregnancy: An Ultrastructural and Immunohistochemical Study. Placenta 2002, 23: 672-684. PMID: 12361686, DOI: 10.1053/plac.2002.0841.Peer-Reviewed Original ResearchConceptsGlandular epitheliumEarly pregnancyTrophoblastic invasionEarly gestationClear cellsDark cellsImmunoreactivity of PCNAEpithelial cellsEarly human pregnancyHuman endometrial epitheliumApocrine secretory activityEndothelial marker CD31Luminal epithelial cellsEarly gestation periodCell nuclear antigenHuman pregnancyEndometrial cellsMenstrual cycleImmunohistochemical studyEndometrial epitheliumLuminal epitheliumSurface epitheliumProminent nucleoliPregnancyUterine secretions
2001
Interleukin 8 production and interleukin 8 receptor expression in human myometrium and leiomyoma
Senturk L, Sozen I, Gutierrez L, Arici A. Interleukin 8 production and interleukin 8 receptor expression in human myometrium and leiomyoma. American Journal Of Obstetrics And Gynecology 2001, 184: 559-566. PMID: 11262453, DOI: 10.1067/mob.2001.111160.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, NorthernCell DivisionDose-Response Relationship, DrugEnzyme-Linked Immunosorbent AssayFemaleGonadotropin-Releasing HormoneHumansImmunohistochemistryInterleukin-1Interleukin-8KineticsLeiomyomaMyometriumReceptors, Interleukin-8ARNA, MessengerTumor Cells, CulturedTumor Necrosis Factor-alphaUterine NeoplasmsConceptsInterleukin-8 productionTumor necrosis factor alphaNecrosis factor alphaInterleukin-8Factor alphaInterleukin-1alphaMyometrial cellsCell proliferationInterleukin-8 receptor expressionGonadotropin-releasing hormone agonistType APotent chemoattractant cytokinesDose-dependent increaseMyometrial cell proliferationMessenger ribonucleic acid expressionDose-dependent inhibitionEnzyme-linked immunosorbentRibonucleic acid expressionLeiomyomatous tissueLeiomyomatous uterusHormone agonistHuman myometriumReceptor expressionChemoattractant cytokinesMyometrial tissue
2000
Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation
Arici A, Sozen I. Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation. Fertility And Sterility 2000, 73: 1006-1011. PMID: 10785229, DOI: 10.1016/s0015-0282(00)00418-0.Peer-Reviewed Original ResearchConceptsTGF-beta3 mRNA levelsLeiomyoma cell proliferationCell proliferationLeiomyoma cellsFibronectin expressionMRNA levelsLeiomyoma samplesProliferative phase samplesTGF-beta3 mRNAUniversity Medical CenterFibronectin mRNA expressionExpression of fibronectinMedical CenterFibrogenic processMAIN OUTCOMESex steroidsMidsecretory phaseMyometrial cellsMyometrial samplesLeiomyomaTGF-beta3MRNA expressionGrowth-promoting effectMyometriumGrowth factor β3
1999
Tumor Necrosis Factor-α Stimulates Proliferation of Rat Ovarian Theca-Interstitial Cells1
Spaczynski R, Arici A, Duleba A. Tumor Necrosis Factor-α Stimulates Proliferation of Rat Ovarian Theca-Interstitial Cells1. Biology Of Reproduction 1999, 61: 993-998. PMID: 10491635, DOI: 10.1095/biolreprod61.4.993.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeTNF-alphaTheca-interstitial cellsOvarian theca-interstitial cellsRat Ovarian Theca-Interstitial CellsInsulin-like growth factor ISerum TNF-alphaGrowth factor II cell proliferationDose-dependent fashionCytometry DNA analysisEffect of insulinOvary syndromeOvarian functionRat TTumor necrosisPathophysiologic roleTotal cell countProliferative indexCell countPotent modulatorFactor IIncorporation assayIGFInsulinProliferation and Differentiation of Rat Theca-Interstitial Cells: Comparison of Effects Induced by Platelet-Derived Growth Factor and Insulin-Like Growth Factor-I1
Duleba A, Spaczynski R, Arici A, Carbone R, Behrman H. Proliferation and Differentiation of Rat Theca-Interstitial Cells: Comparison of Effects Induced by Platelet-Derived Growth Factor and Insulin-Like Growth Factor-I1. Biology Of Reproduction 1999, 60: 546-550. PMID: 10026097, DOI: 10.1095/biolreprod60.3.546.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factorInsulin-like growth factorTheca-interstitial cellsGrowth factorRat theca-interstitial cellsImmature Sprague-Dawley ratsI cellsSprague-Dawley ratsDose-dependent increaseDNA synthesisComparison of effectsActive cellsIGFFlow cytometryThymidine incorporationStimulatory effectProliferationCell countingCytometryCellsDehydrogenase activityTotal numberIndividual subpopulationsProportionDividing cells
1998
Expression and Hormonal Regulation of Monocyte Chemotactic Protein-1 in Myometrium and Leiomyomata
Sozen I, Olive D, Arici A. Expression and Hormonal Regulation of Monocyte Chemotactic Protein-1 in Myometrium and Leiomyomata. Fertility And Sterility 1998, 69: 1095-1102. PMID: 9627299, DOI: 10.1016/s0015-0282(98)00072-7.Peer-Reviewed Original ResearchConceptsMCP-1 mRNA levelsChemotactic protein-1MCP-1Leiomyoma cellsSex steroidsHigher MCP-1 levelsSteroid hormonesMCP-1 protein productionMonocyte chemotactic protein-1MCP-1 levelsMRNA levelsProtein 1Proliferative phase samplesImmunoreactive MCP-1MCP-1 expressionUniversity Medical CenterLeiomyoma cell proliferationParacrine growth factorMCP-1 mRNAGrowth stimulatory effectMessenger RNA levelsPathogenesis of leiomyomaLocal immunityGnRH analoguesProspective studyInterleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1
Arici A, Seli E, Zeyneloglu H, Senturk L, Oral E, Olive D. Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 1201-1205. PMID: 9543141, DOI: 10.1210/jcem.83.4.4743.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsIL-8 productionInterleukin-8Sex steroid hormonesAutocrine growth factorGrowth factorEndometrial cellsCell proliferationSteroid hormonesStromal cellsEndometrial stromal cell proliferationNeutrophil chemoattractant/Potential autocrine growth factorProliferation of endometriumOligonucleotide treatmentPathogenesis of endometriosisProliferation inhibitory effectPotent angiogenic agentStromal cell proliferationConcentration-dependent inhibitionNumber of cytokinesConcentration-dependent increaseAntisense oligonucleotide treatmentEndometrial functionSpecific growth factors