Tumor Necrosis Factor-α Stimulates Proliferation of Rat Ovarian Theca-Interstitial Cells1
Spaczynski R, Arici A, Duleba A. Tumor Necrosis Factor-α Stimulates Proliferation of Rat Ovarian Theca-Interstitial Cells1. Biology Of Reproduction 1999, 61: 993-998. PMID: 10491635, DOI: 10.1095/biolreprod61.4.993.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeTNF-alphaTheca-interstitial cellsOvarian theca-interstitial cellsRat Ovarian Theca-Interstitial CellsInsulin-like growth factor ISerum TNF-alphaGrowth factor II cell proliferationDose-dependent fashionCytometry DNA analysisEffect of insulinOvary syndromeOvarian functionRat TTumor necrosisPathophysiologic roleTotal cell countProliferative indexCell countPotent modulatorFactor IIncorporation assayIGFInsulinProliferation and Differentiation of Rat Theca-Interstitial Cells: Comparison of Effects Induced by Platelet-Derived Growth Factor and Insulin-Like Growth Factor-I1
Duleba A, Spaczynski R, Arici A, Carbone R, Behrman H. Proliferation and Differentiation of Rat Theca-Interstitial Cells: Comparison of Effects Induced by Platelet-Derived Growth Factor and Insulin-Like Growth Factor-I1. Biology Of Reproduction 1999, 60: 546-550. PMID: 10026097, DOI: 10.1095/biolreprod60.3.546.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factorInsulin-like growth factorTheca-interstitial cellsGrowth factorRat theca-interstitial cellsImmature Sprague-Dawley ratsI cellsSprague-Dawley ratsDose-dependent increaseDNA synthesisComparison of effectsActive cellsIGFFlow cytometryThymidine incorporationStimulatory effectProliferationCell countingCytometryCellsDehydrogenase activityTotal numberIndividual subpopulationsProportionDividing cells