2000
Hyperinsulinism and Its Interaction With Hyperandrogenism in Polycystic Ovary Syndrome
Sozen I, Arici A. Hyperinsulinism and Its Interaction With Hyperandrogenism in Polycystic Ovary Syndrome. Obstetrical & Gynecological Survey 2000, 55: 321-328. PMID: 10804539, DOI: 10.1097/00006254-200005000-00026.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeInsulin resistanceOvary syndromeGenetic predispositionCommon endocrine disorderInsulin receptorRole of insulinHyperinsulinemic hyperandrogenismEndocrine disordersReproductive ageHyperandrogenismIndependent factorsHyperinsulinismPostbinding defectComputerized searchSyndromeSignificant subgroupReceptor signal transductionEnglish literatureRelevant studiesVicious cycleReceptorsInsulin genePredispositionPossible mechanism
1999
Tumor Necrosis Factor-α Stimulates Proliferation of Rat Ovarian Theca-Interstitial Cells1
Spaczynski R, Arici A, Duleba A. Tumor Necrosis Factor-α Stimulates Proliferation of Rat Ovarian Theca-Interstitial Cells1. Biology Of Reproduction 1999, 61: 993-998. PMID: 10491635, DOI: 10.1095/biolreprod61.4.993.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeTNF-alphaTheca-interstitial cellsOvarian theca-interstitial cellsRat Ovarian Theca-Interstitial CellsInsulin-like growth factor ISerum TNF-alphaGrowth factor II cell proliferationDose-dependent fashionCytometry DNA analysisEffect of insulinOvary syndromeOvarian functionRat TTumor necrosisPathophysiologic roleTotal cell countProliferative indexCell countPotent modulatorFactor IIncorporation assayIGFInsulin