2001
Interleukin 8 production and interleukin 8 receptor expression in human myometrium and leiomyoma
Senturk L, Sozen I, Gutierrez L, Arici A. Interleukin 8 production and interleukin 8 receptor expression in human myometrium and leiomyoma. American Journal Of Obstetrics And Gynecology 2001, 184: 559-566. PMID: 11262453, DOI: 10.1067/mob.2001.111160.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, NorthernCell DivisionDose-Response Relationship, DrugEnzyme-Linked Immunosorbent AssayFemaleGonadotropin-Releasing HormoneHumansImmunohistochemistryInterleukin-1Interleukin-8KineticsLeiomyomaMyometriumReceptors, Interleukin-8ARNA, MessengerTumor Cells, CulturedTumor Necrosis Factor-alphaUterine NeoplasmsConceptsInterleukin-8 productionTumor necrosis factor alphaNecrosis factor alphaInterleukin-8Factor alphaInterleukin-1alphaMyometrial cellsCell proliferationInterleukin-8 receptor expressionGonadotropin-releasing hormone agonistType APotent chemoattractant cytokinesDose-dependent increaseMyometrial cell proliferationMessenger ribonucleic acid expressionDose-dependent inhibitionEnzyme-linked immunosorbentRibonucleic acid expressionLeiomyomatous tissueLeiomyomatous uterusHormone agonistHuman myometriumReceptor expressionChemoattractant cytokinesMyometrial tissue
2000
Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation
Arici A, Sozen I. Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation. Fertility And Sterility 2000, 73: 1006-1011. PMID: 10785229, DOI: 10.1016/s0015-0282(00)00418-0.Peer-Reviewed Original ResearchConceptsTGF-beta3 mRNA levelsLeiomyoma cell proliferationCell proliferationLeiomyoma cellsFibronectin expressionMRNA levelsLeiomyoma samplesProliferative phase samplesTGF-beta3 mRNAUniversity Medical CenterFibronectin mRNA expressionExpression of fibronectinMedical CenterFibrogenic processMAIN OUTCOMESex steroidsMidsecretory phaseMyometrial cellsMyometrial samplesLeiomyomaTGF-beta3MRNA expressionGrowth-promoting effectMyometriumGrowth factor β3