2010
Cell Death and Fibrogenesis
Mehal W, Imaeda A. Cell Death and Fibrogenesis. Seminars In Liver Disease 2010, 30: 226-231. PMID: 20665375, PMCID: PMC3219753, DOI: 10.1055/s-0030-1255352.BooksConceptsHepatic stellate cellsQuiescent hepatic stellate cellsChronic liver injuryNatural killer cellsCell deathHIV infectionLiver injuryNK cellsKiller cellsAntifibrotic effectsImmune suppressionImmune cellsProfibrotic effectsStellate cellsHepatocyte deathHSC apoptosisDeathCellular deathFibrosisCellular debrisMatrix depositionHSC deathSurvival signalsApoptotic bodiesProapoptotic signalsWhat Is Most Important to Patients when Deciding about Colorectal Screening?
Imaeda A, Bender D, Fraenkel L. What Is Most Important to Patients when Deciding about Colorectal Screening? Journal Of General Internal Medicine 2010, 25: 688-693. PMID: 20309740, PMCID: PMC2881957, DOI: 10.1007/s11606-010-1318-9.Peer-Reviewed Original ResearchConceptsColon capsule endoscopyFecal occult blood testingTest characteristicsCapsule endoscopyBackgroundColorectal cancer (CRC) screeningOccult blood testingPrimary care clinicsRisk of tearsCT colonographyPoor health statusPreference-sensitive decisionsColorectal screeningCare clinicsBlood testingCancer screeningColon preparationExcellent healthElicit patientVA hospitalsPatientsPatient experienceHealth statusTest preferenceColonoscopyPilot study
2009
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome
Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, Sutterwala FS, Flavell RA, Mehal WZ. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. Journal Of Clinical Investigation 2009, 119: 305-314. PMID: 19164858, PMCID: PMC2631294, DOI: 10.1172/jci35958.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAnalgesics, Non-NarcoticAnimalsApoptosisAspirinCarrier ProteinsCaspase InhibitorsCell LineCyclooxygenase InhibitorsDose-Response Relationship, DrugHumansImmunity, InnateInflammationInterleukin-18Interleukin-1betaLiverMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinSignal TransductionToll-Like Receptor 9ConceptsLiver injuryIL-1betaNALP3 inflammasomeHepatocyte deathAcetaminophen-induced liver injuryCaspase-1Proinflammatory cytokine activationInnate immune activationSterile inflammatory responseType of injuryCOX-1 inhibitionMature IL-1betaPotential therapeutic approachSinusoidal endothelial cellsOverall tissue injuryIL-18Immune activationProinflammatory cytokinesTLR9 antagonistInitial insultInflammatory responseTissue injuryProtective effectCytokine activationTherapeutic approaches
2007
A pilot project examining the predicted preferences of patients and physicians in the primary prophylaxis of variceal hemorrhage
Longacre AV, Imaeda A, Garcia‐Tsao G, Fraenkel L. A pilot project examining the predicted preferences of patients and physicians in the primary prophylaxis of variceal hemorrhage. Hepatology 2007, 47: 169-176. PMID: 17935182, PMCID: PMC2674014, DOI: 10.1002/hep.21945.Peer-Reviewed Original ResearchConceptsEndoscopic variceal ligationProcedure-related bleedingVariceal hemorrhagePrimary prophylaxisPreferences of patientsRoute of administrationSexual dysfunctionFirst-line therapyShortness of breathIndividual patient preferencesUntreated patientsEsophageal varicesVariceal ligationPrimary preventionPatient preferencesRisk of fatigueTreatment preferencesProphylaxisSide effectsHemorrhagePatientsBleedingPhysiciansFuture guidelinesHypotension