Mechanism of desensitization of the cloned vasopressin V1a receptor expressed in Xenopus oocytes
Nathanson MH, Burgstahler AD, Orloff JJ, Mani A, Moyer MS. Mechanism of desensitization of the cloned vasopressin V1a receptor expressed in Xenopus oocytes. American Journal Of Physiology 1994, 267: c94-c103. PMID: 8048495, DOI: 10.1152/ajpcell.1994.267.1.c94.Peer-Reviewed Original ResearchConceptsVasopressin V1a receptorV1a receptorReceptor desensitizationXenopus oocytesCyclic monophosphateMechanism of desensitizationG protein-mediated increasesProtein-mediated increasePretreatment of oocytesSubsequent microinjectionReceptor binding sitesMin of exposureProtein kinase C.Protein kinase CCytosolic Ca2Maximal stimulationDesensitizationReceptorsPhorbol dibutyrateKinase C.Inositol trisphosphateKinase CVasopressinOocytesConfocal microscopy