Dyrk1b promotes autophagy during skeletal muscle differentiation by upregulating 4e-bp1
Bhat N, Narayanan A, Fathzadeh M, Shah K, Dianatpour M, Abou Ziki MD, Mani A. Dyrk1b promotes autophagy during skeletal muscle differentiation by upregulating 4e-bp1. Cellular Signalling 2021, 90: 110186. PMID: 34752933, PMCID: PMC8712395, DOI: 10.1016/j.cellsig.2021.110186.Peer-Reviewed Original ResearchConceptsSkeletal muscle differentiationMuscle differentiationC2C12 cellsHuman skeletal muscle developmentSkeletal muscle developmentGlobal gene networksPost-transcriptional targetEmbryonic lethalGene networksZebrafish embryosMyofiber differentiationOverexpression approachesMuscle developmentCRISPR/DYRK1BRare gainDownstream targetsTranslational inhibitorKey regulatorUntargeted proteomicsFunction mutationsAutophagic fluxEnhances AutophagyDifferentiationAutophagy