2023
Shared Lifestyle-Related Risk Factors of Cardiovascular Disease and Cancer: Evidence for Joint Prevention
Masoudkabir F, Mohammadifard N, Mani A, Ignaszewski A, Davis M, Vaseghi G, Mansourian M, Franco C, Gotay C, Sarrafzadegan N. Shared Lifestyle-Related Risk Factors of Cardiovascular Disease and Cancer: Evidence for Joint Prevention. The Scientific World JOURNAL 2023, 2023: 2404806. PMID: 37520844, PMCID: PMC10386903, DOI: 10.1155/2023/2404806.Peer-Reviewed Original Research
2022
Does Opium Consumption Have Shared Impact on Atherosclerotic Cardiovascular Disease and Cancer?
Masoudkabir F, Malekzadeh R, Yavari N, Zendehdel K, Mani A, Vasheghani-Farahani A, Ignaszewski A, Toma M, Roayaei P, Turk-Adawi K, Sarrafzadegan N. Does Opium Consumption Have Shared Impact on Atherosclerotic Cardiovascular Disease and Cancer? Archives Of Iranian Medicine 2022, 25: 50-63. PMID: 35128912, DOI: 10.34172/aim.2022.08.Peer-Reviewed Original ResearchConceptsAtherosclerotic cardiovascular diseaseRisk factorsOpium consumptionOpium abuseCardiovascular diseaseRisk of ASCVDLifestyle-related risk factorsASCVD risk factorsInadequate physical activityExcessive alcohol consumptionTypes of cancerKinds of cancersPotential carcinogenic effectsDiabetes mellitusPathophysiologic mechanismsOpium abusersUnhealthy dietPhysical activityCurrent evidenceAlcohol consumptionHeart attackCancerCarcinogenic effectsPoor controlDisease
2018
The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome
Abou Ziki M, Mani A. The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome. Nutrition Research 2018, 70: 18-25. PMID: 30049588, PMCID: PMC6320319, DOI: 10.1016/j.nutres.2018.06.009.Peer-Reviewed Original ResearchConceptsMetabolic syndromeLow density lipoprotein clearanceVascular smooth muscle proliferationEnd-organ complicationsCanonical WntSmooth muscle proliferationLow-density lipoproteinDe novo lipogenesisInsulin receptor expressionTranscription factor 7Growth factor βRas homolog gene family member AExtracellular matrix depositionCardiometabolic abnormalitiesLiver inflammationFamily member AInsulin resistanceLipoprotein clearanceLiver fatHepatic fibrosisSevere manifestationsLDL receptor-related protein 6Receptor expressionCardiovascular diseaseMuscle proliferation
2017
Application of Whole Exome Sequencing in the Clinical Diagnosis and Management of Inherited Cardiovascular Diseases in Adults
Seidelmann SB, Smith E, Subrahmanyan L, Dykas D, Abou Ziki MD, Azari B, Hannah-Shmouni F, Jiang Y, Akar JG, Marieb M, Jacoby D, Bale AE, Lifton RP, Mani A. Application of Whole Exome Sequencing in the Clinical Diagnosis and Management of Inherited Cardiovascular Diseases in Adults. Circulation Genomic And Precision Medicine 2017, 10: e001573. PMID: 28087566, PMCID: PMC5245580, DOI: 10.1161/circgenetics.116.001573.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingSudden cardiac deathCardiovascular diseaseClinical diagnosisExome sequencingCardiac deathInherited cardiovascular diseaseCentre of careNovel candidate genesValuable screening toolAdult patientsRisk stratificationPrimary insultCardiac functionGenetic testingScreening toolDiagnosisCVD genesGenetic causeCardiovascular geneticsGenetic panelSuccess rateExome databasesPotential disease associationsPatients
2015
New targets to treat obesity and the metabolic syndrome
Martin KA, Mani MV, Mani A. New targets to treat obesity and the metabolic syndrome. European Journal Of Pharmacology 2015, 763: 64-74. PMID: 26001373, PMCID: PMC4573317, DOI: 10.1016/j.ejphar.2015.03.093.Peer-Reviewed Original ResearchConceptsMetabolic syndromeCardiovascular diseaseGlucagon-like peptide-1 receptor agonistsPancreatic lipase inhibitor orlistatSingle CVD risk factorPeptide-1 receptor agonistsCVD risk factorsEpidemic of obesityLong-term treatmentType 2 diabetesLipase inhibitor orlistatDipeptidyl peptidase IV inhibitorsAnti-diabetic drugsFuture drug developmentTruncal obesitySerotonergic drugsReceptor agonistRisk factorsMelanocortin systemObesityMetabolic traitsSyndromeMetabolic profileIV inhibitorsNew targets
2012
Prevalence of Obesity and Traditional Cardiovascular Risk Factors in South Asians
Khanna P, Mani A. Prevalence of Obesity and Traditional Cardiovascular Risk Factors in South Asians. Current Cardiovascular Risk Reports 2012, 6: 112-119. DOI: 10.1007/s12170-012-0220-x.Peer-Reviewed Original ResearchRisk factorsCardiovascular diseaseSouth AsiansTraditional cardiovascular risk factorsCardiovascular risk factorsCVD risk factorsPrevalence of obesityLifestyle factorsNovel biomarkersGenetic predispositionHealthcare providersDisease controlNovel therapeuticsMajor causeGenetic causePrevalenceObesityWestern worldAsiansCauseImportant contributorDiabetesSpecific differencesFactorsMortality