Leveraging altered lipid metabolism in treating B cell malignancies
Lee J, Mani A, Shin M, Krauss R. Leveraging altered lipid metabolism in treating B cell malignancies. Progress In Lipid Research 2024, 95: 101288. PMID: 38964473, PMCID: PMC11347096, DOI: 10.1016/j.plipres.2024.101288.Peer-Reviewed Original ResearchB-cell malignanciesMalignant B cellsB cell receptorAltered lipid metabolismLipid metabolismOncogenic signalingB cellsTreating B-cell malignanciesReprogram lipid metabolismLipid raft integrityB-cell receptor activationHeterogeneous blood cancerImprove risk stratificationUncontrolled cell proliferationB cell activationRaft integrityLipid raftsMYC translocationCytotoxic therapyHeightened metabolic demandsGenetic driversSignaling cascadesMalignant subtypeRisk stratificationObese individuals