2024
Anticoagulation in Patients with Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization
Kim T, DeWan A, Murray M, Wang H, Mani A, Mena-Hurtado C, Guzman R, Ochoa Chaar C. Anticoagulation in Patients with Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization. Annals Of Vascular Surgery 2024, 105: 150-157. PMID: 38593922, DOI: 10.1016/j.avsg.2024.02.006.Peer-Reviewed Original ResearchPremature peripheral arterial diseaseAntiplatelet therapyVascular Quality InitiativeArtery diseaseAdjunct to antiplatelet therapyReturn to the operating roomPost-operative anticoagulationCompared to patientsPostoperative antiplatelet therapyOne-year outcomesCongestive heart failureLower extremity revascularizationMajor adverse limb eventsCoronary artery diseaseEffects of anticoagulantsAmputation-free survivalEarly onset of diseaseAdverse limb eventsPeripheral vascular interventionsOnset of diseasePeripheral arterial diseaseLower-extremity revascularizationPropensity score matchingPerioperative mortalityBaseline characteristics
2022
Major Adverse Limb Events Among Patients with Premature Peripheral Artery Disease Compared with Those at the Common Age Undergoing Revascularization in the Vascular Quality Initiative
Kim TI, Loh S, DeWan A, Murray M, Mojibian H, Mani A, Mena-Hurtado C, Ochoa Chaar CI. Major Adverse Limb Events Among Patients with Premature Peripheral Artery Disease Compared with Those at the Common Age Undergoing Revascularization in the Vascular Quality Initiative. Annals Of Vascular Surgery 2022, 87: 188-197. PMID: 35926786, DOI: 10.1016/j.avsg.2022.07.007.Peer-Reviewed Original ResearchConceptsMajor adverse limb eventsChronic limb-threatening ischemiaLower extremity revascularizationAdverse limb eventsVascular Quality InitiativePeripheral artery diseaseYears of ageCommon ageLimb eventsArtery diseaseOutcomes of patientsLimb-threatening ischemiaGroup of patientsInsulin-dependent diabetesProportional hazards regressionQuality InitiativeUndergoing revascularizationMedical optimizationCurrent smokersD diseaseExtremity revascularizationPatient agePatients 60Medical therapyHazards regressionEscalation of Antithrombotic Therapy in Patients With Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization
Kim T, DeWan A, Murray M, Wang H, Mani A, Mena-Hurtado C, Guzman R, Chaar C. Escalation of Antithrombotic Therapy in Patients With Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization. Journal Of Vascular Surgery 2022, 75: e281. DOI: 10.1016/j.jvs.2022.03.640.Peer-Reviewed Original ResearchLower Extremity Revascularization Among Patients With Premature Peripheral Artery Disease Compared To Patients At The Common Age Of Presentation In The Vascular Quality Initiative
Kim T, Loh S, Dewan A, Murray M, Mojibian H, Mani A, Mena-Hurtado C, Chaar C. Lower Extremity Revascularization Among Patients With Premature Peripheral Artery Disease Compared To Patients At The Common Age Of Presentation In The Vascular Quality Initiative. Annals Of Vascular Surgery 2022, 79: 400-401. DOI: 10.1016/j.avsg.2021.12.049.Peer-Reviewed Original ResearchMajor adverse limb eventsLower extremity revascularizationPeripheral artery diseaseCommon ageExtremity revascularizationArtery diseaseAdverse limb eventsDe novo diseaseOutcomes of patientsVascular Quality InitiativeInsulin-dependent diabetesSevere disease burdenNovo diseaseTASC classificationConclusions PatientsPatient agePatients 60Poor outcomeDisease burdenSevere diseaseLimb eventsPatientsLogistic regressionOne-yearDisease
2021
Wnt Signaling Cascades and Their Role in Coronary Artery Health and Disease
Weerackoon N, Gunawardhana KL, Mani A. Wnt Signaling Cascades and Their Role in Coronary Artery Health and Disease. Journal Of Cellular Signaling 2021, 2: 52-62. PMID: 33969358, PMCID: PMC8098721, DOI: 10.33696/signaling.2.035.Peer-Reviewed Original ResearchCoronary artery diseaseVascular smooth muscle cellsLow-density lipoproteinPlaque erosionDisease processWnt pathwayAdult cardiovascular diseaseDistinct disease processesSmooth muscle proliferationType 2 diabetesCause of deathMajor congenital defectsModified low-density lipoproteinSmooth muscle cellsWnt/β-catenin signalingCoronary artery healthCanonical Wnt/β-catenin signalingAggregation of monocytesActivation of WntΒ-catenin signalingArtery diseaseEndothelial cell defectsEndothelial dysfunctionWnt/CaVascular inflammation
2020
The role of Wnt signalling in development of coronary artery disease and its risk factors
Liu Y, Neogi A, Mani A. The role of Wnt signalling in development of coronary artery disease and its risk factors. Open Biology 2020, 10: 200128. PMID: 33081636, PMCID: PMC7653355, DOI: 10.1098/rsob.200128.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBiomarkersCarrier ProteinsCell DifferentiationCell MovementCoronary Artery DiseaseDisease SusceptibilityEndotheliumGene Expression RegulationHumansLipid MetabolismMacrophage ActivationMacrophagesMyocytes, Smooth MuscleProtein BindingRisk FactorsWnt ProteinsWnt Signaling PathwayConceptsCoronary artery diseaseArtery diseaseRole of WntVascular smooth muscle cellsEndothelial cell dysfunctionReduced blood flowLow-density lipoproteinModified low-density lipoproteinWnt pathwaySmooth muscle cellsNon-canonical Wnt/CaAggregation of monocytesTissue-resident macrophagesChest painEndothelial dysfunctionWnt/CaHeart failureLuminal narrowingCascade of eventsPathophysiological mechanismsMyocardial infarctionRisk factorsHeart diseaseCell dysfunctionInflammatory reaction
2018
TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia
Srivastava R, Rolyan H, Xie Y, Li N, Bhat N, Hong L, Esteghamat F, Adeniran A, Geirsson A, Zhang J, Ge G, Nobrega M, Martin KA, Mani A. TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia. Arteriosclerosis Thrombosis And Vascular Biology 2018, 39: 250-262. PMID: 30567484, PMCID: PMC6365015, DOI: 10.1161/atvbaha.118.311830.Peer-Reviewed Original ResearchConceptsInjury-induced intimal hyperplasiaIntimal hyperplasiaObstructive coronary artery diseaseVascular smooth muscle cell dedifferentiationSmooth muscle cell dedifferentiationVascular Smooth Muscle Cell PlasticityLRP6 mutant miceOverexpression of TCF7L2Coronary artery diseaseVascular smooth muscle cellsMultiple mouse modelsMuscle cell dedifferentiationWild-type littermatesSmooth muscle cellsRole of TCF7L2Smooth Muscle Cell PlasticityVascular smooth muscle cell differentiationMuscle cell plasticitySmooth muscle cell differentiationArtery diseaseSM-MHCMouse modelCell cycle inhibitorsHaploinsufficient miceHyperplasia
2016
IMPORTIN 4 ACTS AS A GENETIC MODIFIER OF LAMIN A/C ARG644CYS MUTATION IN PREDISPOITION FOR PREMATURE CORONARY ARTERY DISEASE
Ziki M, Smith E, Seidelmann S, Mani A. IMPORTIN 4 ACTS AS A GENETIC MODIFIER OF LAMIN A/C ARG644CYS MUTATION IN PREDISPOITION FOR PREMATURE CORONARY ARTERY DISEASE. Journal Of The American College Of Cardiology 2016, 67: 589. DOI: 10.1016/s0735-1097(16)30590-3.Peer-Reviewed Original Research
2015
Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease
Srivastava R, Zhang J, Go GW, Narayanan A, Nottoli TP, Mani A. Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease. Cell Reports 2015, 13: 746-759. PMID: 26489464, PMCID: PMC4626307, DOI: 10.1016/j.celrep.2015.09.028.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseLRP6 activityArtery diseaseObstructive coronary artery diseaseHigh-fat dietVascular smooth muscle cell differentiationMuscle cell plasticitySmooth muscle cell differentiationAtherosclerotic burdenMedial hyperplasiaCarotid injuryArterial diseaseVascular obstructionNeointima formationTherapeutic targetWnt3a administrationIntact WntVSMC differentiationKnockout backgroundDiseaseMiceVessel wallNon-canonical WntCoreceptor LRP6Cell plasticity