Life-threatening hypertriglyceridemia-induced pancreatitis related to alectinib successfully treated by plasmapheresis: A review of the literature on metabolic toxicities associated with anaplastic lymphoma kinase inhibitors
Rao A, Reddy A, Dinunno C, Elali I. Life-threatening hypertriglyceridemia-induced pancreatitis related to alectinib successfully treated by plasmapheresis: A review of the literature on metabolic toxicities associated with anaplastic lymphoma kinase inhibitors. Journal Of Oncology Pharmacy Practice 2020, 26: 1533-1537. PMID: 32054410, DOI: 10.1177/1078155220904141.Peer-Reviewed Original ResearchConceptsAnaplastic lymphoma kinase inhibitorsTriglyceride levelsAcute pancreatitisKinase inhibitorsMetastatic non-small cell lung cancerNon-small cell lung cancerHypertriglyceridemia-induced acute pancreatitisAnaplastic lymphoma kinase (ALK) rearrangementAnaplastic lymphoma kinase (ALK) mutationsAggressive multidisciplinary managementHypertriglyceridemia-induced pancreatitisPatient's triglyceride levelStage IIIA adenocarcinomaCommon adverse effectsTraditional risk factorsCell lung cancerRight hilar massStandard of careTyrosine kinase inhibitorsEpigastric painConcurrent chemoradiationIntravenous hydrationRespiratory failureRight hilumElevated triglycerides