2024
Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity
Markicevic M, Mandino F, Toyonaga T, Cai Z, Fesharaki-Zadeh A, Shen X, Strittmatter S, Lake E. Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity. Journal Of Neurotrauma 2024 PMID: 39096127, DOI: 10.1089/neu.2024.0095.Peer-Reviewed Original ResearchChronic variable stressRegional homogeneityFunctional brain abnormalitiesSynapse densityMild closed-head injuryClosed-head injuryTraumatic brain injuryTreat traumatic brain injuryNeurobiological alterationsMild head injuryVariable stressBrain abnormalitiesPositron emission tomographyMultimodal studiesSynaptic densityMagnetic resonance imagingBrain imagingBrain injuryInduce synapse lossFMRIInjured miceMouse modelEmission tomographyResonance imagingCompensatory mechanisms
2020
Increased Behavioral Deficits and Inflammation in a Mouse Model of Co-Morbid Traumatic Brain Injury and Post-Traumatic Stress Disorder
Fesharaki-Zadeh A, Miyauchi JT, St. Laurent-Arriot K, Tsirka SE, Bergold PJ. Increased Behavioral Deficits and Inflammation in a Mouse Model of Co-Morbid Traumatic Brain Injury and Post-Traumatic Stress Disorder. ASN Neuro 2020, 12: 1759091420979567. PMID: 33342261, PMCID: PMC7755938, DOI: 10.1177/1759091420979567.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryPost-traumatic stress disorderChi groupBrain injuryBarnes mazeCo-morbid traumatic brain injuryMale C57/BL6 miceCognitive deficitsComorbid post-traumatic stress disorderC57/BL6 miceStress disorderClosed-head modelIba-1 levelsChronic variable stress modelActive place avoidancePlace avoidanceGreater cognitive deficitsNeuroinflammatory outcomesBasal anxiety levelsCVS groupSham treatmentBL6 miceBehavioral deficitsMouse modelKey underlying mechanism