2021
Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis
Rocha M, Wang D, Avila-Quintero V, Bloch MH, Kaffman A. Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis. Translational Psychiatry 2021, 11: 231. PMID: 33879774, PMCID: PMC8058062, DOI: 10.1038/s41398-021-01352-4.Peer-Reviewed Original ResearchConceptsEarly life stressNovel object recognitionMorris water mazeDifferent rodent modelsContextual fear conditioningMaternal separationHippocampal-dependent memoryVentral hippocampusDorsal hippocampusRodent modelsLife stressAbnormal hippocampal developmentStandardized mean differenceSimilar cognitive deficitsWeb of ScienceModerate effect sizeCFC taskFunctional deficitsFear conditioningInclusion criteriaPreclinical studiesReduced freezingHippocampal developmentLimited beddingWater maze
2020
Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents
Wang D, Levine JLS, Avila-Quintero V, Bloch M, Kaffman A. Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents. Translational Psychiatry 2020, 10: 174. PMID: 32483128, PMCID: PMC7264128, DOI: 10.1038/s41398-020-0856-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnxietyAnxiety DisordersBehavior, AnimalExploratory BehaviorMaternal DeprivationMiceRatsRodentiaConceptsOpen field testEarly life stressSystematic reviewEffects of MSEffects of ELSAnxiety-like behaviorDefensive behaviorAnxiogenic effectsMaternal separationRodent modelsRatsEarly adversityMiceAbility of MSLife stressLack of standardizationChildhood maltreatmentRodentsExploratory behaviorEffect sizeInconsistent resultsELS modelImportant differencesReviewMS protocol
2016
Early life stress perturbs the maturation of microglia in the developing hippocampus
Delpech JC, Wei L, Hao J, Yu X, Madore C, Butovsky O, Kaffman A. Early life stress perturbs the maturation of microglia in the developing hippocampus. Brain Behavior And Immunity 2016, 57: 79-93. PMID: 27301858, PMCID: PMC5010940, DOI: 10.1016/j.bbi.2016.06.006.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsHippocampusMaternal DeprivationMiceMice, Inbred BALB CMicrogliaStress, PsychologicalConceptsEarly life stressHippocampal developmentLife stressPhagocytic activityAbnormal hippocampal developmentNormal hippocampal developmentMorphology of microgliaPostnatal day 28Vivo phagocytic activityImpairs hippocampal functionMaturation of microgliaImmune panelHippocampal microgliaMicroglial activityMicroglial functionNormal cell numbersSynaptic maturationOld miceMicrogliaMouse modelRodent modelsSynaptic pruningDay 28Old pupsHippocampus
2015
Early-Life Stress Perturbs Key Cellular Programs in the Developing Mouse Hippocampus
Wei L, Hao J, Lacher RK, Abbott T, Chung L, Colangelo CM, Kaffman A. Early-Life Stress Perturbs Key Cellular Programs in the Developing Mouse Hippocampus. Developmental Neuroscience 2015, 37: 476-488. PMID: 26068561, PMCID: PMC4644446, DOI: 10.1159/000430861.Peer-Reviewed Original ResearchConceptsEarly life stressEffects of ELSHippocampal developmentSynaptic maturationAxonal growthExpression of proteinsJuvenile hippocampusJuvenile miceHippocampal functionAbnormal hippocampal developmentNormal axonal growthHippocampal-dependent memoryNormal synaptic developmentHuman imaging studiesTotal protein contentCA1 neuronsSynaptic markersFemale miceMouse modelMouse hippocampusSynaptic pruningAnimal modeMature spinesHippocampusSynaptic proteinsEarly-Life Stress Restricts the Capacity of Adult Progenitor Cells to Differentiate into Neurons
Kaffman A. Early-Life Stress Restricts the Capacity of Adult Progenitor Cells to Differentiate into Neurons. Biological Psychiatry 2015, 77: 307-309. PMID: 25592267, PMCID: PMC4435555, DOI: 10.1016/j.biopsych.2014.11.008.Peer-Reviewed Original Research
2014
Early Life Stress Inhibits Expression of Ribosomal RNA in the Developing Hippocampus
Wei L, Hao J, Kaffman A. Early Life Stress Inhibits Expression of Ribosomal RNA in the Developing Hippocampus. PLOS ONE 2014, 9: e115283. PMID: 25517398, PMCID: PMC4269428, DOI: 10.1371/journal.pone.0115283.Peer-Reviewed Original ResearchConceptsEarly life stressSecond weekHippocampal growthAbnormal hippocampal functionNormal hippocampal developmentNormal mouse hippocampusLife stressMaternal separationMouse hippocampusMouse modelHippocampal developmentHippocampal functionHippocampus developmentNovel molecular mechanismDaily separationHippocampusWeeksDNA methylationInhibits expressionAdulthoodExposureMolecular mechanismsRNA contentGradual declineNormal growth
2011
Early Life Stress Inhibits Expression of a Novel Innate Immune Pathway in the Developing Hippocampus
Wei L, Simen A, Mane S, Kaffman A. Early Life Stress Inhibits Expression of a Novel Innate Immune Pathway in the Developing Hippocampus. Neuropsychopharmacology 2011, 37: 567-580. PMID: 21993208, PMCID: PMC3242319, DOI: 10.1038/npp.2011.239.Peer-Reviewed Original ResearchMeSH KeywordsAcute-Phase ProteinsAnimalsAnimals, NewbornAnxietyBehavior, AnimalCarrier ProteinsCorticosteroneCritical Period, PsychologicalDisease Models, AnimalDown-RegulationFemaleGenomicsHippocampusHumansImmunity, InnateMaleMaternal DeprivationMembrane GlycoproteinsMemory DisordersMiceMice, Inbred BALB CMice, KnockoutNeurogenesisStress, PsychologicalConceptsLipopolysaccharide binding proteinEarly life stressAnxiety-like behaviorLife stressSynaptic pruningNovel innate immune pathwayLBP knockout miceNormal hippocampal developmentNormal synaptic pruningSynaptic marker PSD95Hippocampus of pupsMajor risk factorChronic mental illnessImpairs cognitive functionInnate immune pathwaysPostnatal day 30Hippocampal-dependent memoryAbnormal spine morphologyInnate immune systemNon-human primatesLBP levelsSpine densityMicroglia cellsRisk factorsHippocampal development
2010
Early life stress increases anxiety-like behavior in Balbc mice despite a compensatory increase in levels of postnatal maternal care
Wei L, David A, Duman RS, Anisman H, Kaffman A. Early life stress increases anxiety-like behavior in Balbc mice despite a compensatory increase in levels of postnatal maternal care. Hormones And Behavior 2010, 57: 396-404. PMID: 20096699, PMCID: PMC2849915, DOI: 10.1016/j.yhbeh.2010.01.007.Peer-Reviewed Original Research