Early Life Stress Inhibits Expression of Ribosomal RNA in the Developing Hippocampus
Wei L, Hao J, Kaffman A. Early Life Stress Inhibits Expression of Ribosomal RNA in the Developing Hippocampus. PLOS ONE 2014, 9: e115283. PMID: 25517398, PMCID: PMC4269428, DOI: 10.1371/journal.pone.0115283.Peer-Reviewed Original ResearchConceptsEarly life stressSecond weekHippocampal growthAbnormal hippocampal functionNormal hippocampal developmentNormal mouse hippocampusLife stressMaternal separationMouse hippocampusMouse modelHippocampal developmentHippocampal functionHippocampus developmentNovel molecular mechanismDaily separationHippocampusWeeksDNA methylationInhibits expressionAdulthoodExposureMolecular mechanismsRNA contentGradual declineNormal growth