2021
Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis
Rocha M, Wang D, Avila-Quintero V, Bloch MH, Kaffman A. Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis. Translational Psychiatry 2021, 11: 231. PMID: 33879774, PMCID: PMC8058062, DOI: 10.1038/s41398-021-01352-4.Peer-Reviewed Original ResearchConceptsEarly life stressNovel object recognitionMorris water mazeDifferent rodent modelsContextual fear conditioningMaternal separationHippocampal-dependent memoryVentral hippocampusDorsal hippocampusRodent modelsLife stressAbnormal hippocampal developmentStandardized mean differenceSimilar cognitive deficitsWeb of ScienceModerate effect sizeCFC taskFunctional deficitsFear conditioningInclusion criteriaPreclinical studiesReduced freezingHippocampal developmentLimited beddingWater maze
2015
Early-Life Stress Perturbs Key Cellular Programs in the Developing Mouse Hippocampus
Wei L, Hao J, Lacher RK, Abbott T, Chung L, Colangelo CM, Kaffman A. Early-Life Stress Perturbs Key Cellular Programs in the Developing Mouse Hippocampus. Developmental Neuroscience 2015, 37: 476-488. PMID: 26068561, PMCID: PMC4644446, DOI: 10.1159/000430861.Peer-Reviewed Original ResearchConceptsEarly life stressEffects of ELSHippocampal developmentSynaptic maturationAxonal growthExpression of proteinsJuvenile hippocampusJuvenile miceHippocampal functionAbnormal hippocampal developmentNormal axonal growthHippocampal-dependent memoryNormal synaptic developmentHuman imaging studiesTotal protein contentCA1 neuronsSynaptic markersFemale miceMouse modelMouse hippocampusSynaptic pruningAnimal modeMature spinesHippocampusSynaptic proteins
2011
Early Life Stress Inhibits Expression of a Novel Innate Immune Pathway in the Developing Hippocampus
Wei L, Simen A, Mane S, Kaffman A. Early Life Stress Inhibits Expression of a Novel Innate Immune Pathway in the Developing Hippocampus. Neuropsychopharmacology 2011, 37: 567-580. PMID: 21993208, PMCID: PMC3242319, DOI: 10.1038/npp.2011.239.Peer-Reviewed Original ResearchMeSH KeywordsAcute-Phase ProteinsAnimalsAnimals, NewbornAnxietyBehavior, AnimalCarrier ProteinsCorticosteroneCritical Period, PsychologicalDisease Models, AnimalDown-RegulationFemaleGenomicsHippocampusHumansImmunity, InnateMaleMaternal DeprivationMembrane GlycoproteinsMemory DisordersMiceMice, Inbred BALB CMice, KnockoutNeurogenesisStress, PsychologicalConceptsLipopolysaccharide binding proteinEarly life stressAnxiety-like behaviorLife stressSynaptic pruningNovel innate immune pathwayLBP knockout miceNormal hippocampal developmentNormal synaptic pruningSynaptic marker PSD95Hippocampus of pupsMajor risk factorChronic mental illnessImpairs cognitive functionInnate immune pathwaysPostnatal day 30Hippocampal-dependent memoryAbnormal spine morphologyInnate immune systemNon-human primatesLBP levelsSpine densityMicroglia cellsRisk factorsHippocampal development