Early life stress perturbs the function of microglia in the developing rodent brain: New insights and future challenges
Johnson FK, Kaffman A. Early life stress perturbs the function of microglia in the developing rodent brain: New insights and future challenges. Brain Behavior And Immunity 2017, 69: 18-27. PMID: 28625767, PMCID: PMC5732099, DOI: 10.1016/j.bbi.2017.06.008.Peer-Reviewed Original ResearchConceptsEarly life stressMicroglial functionLife stressAnimal modelsBehavioral abnormalitiesStress-induced neuroinflammationMicroglial cell numberFunction of microgliaMicroglial gene expressionChildhood maltreatmentInnate immune systemMedical complicationsLong-term adultAbnormal maturationMouse modelSynaptic pruningRodent brainImmune systemPhagocytic activityAxonal growthBrain developmentDaily separationFirst weekGene expressionAbnormalities