2021
A regulatory network of microRNAs confers lineage commitment during early developmental trajectories of B and T lymphocytes
Nikhat S, Yadavalli AD, Prusty A, Narayan PK, Palakodeti D, Murre C, Pongubala JMR. A regulatory network of microRNAs confers lineage commitment during early developmental trajectories of B and T lymphocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2104297118. PMID: 34750254, PMCID: PMC8609617, DOI: 10.1073/pnas.2104297118.Peer-Reviewed Original ResearchConceptsMultipotent progenitorsCell type-specific genesDe novo motif analysisLymphocyte developmentLineage-inappropriate genesHematopoietic multipotent progenitorsSilencing of genesType-specific genesGene expression programsNovo motif analysisEarly T-lymphocyte developmentAlternate cell fatesCell-autonomous mannerGene expression patternsLineage determinantsMyeloid differentiation potentialExpression programsCell fateMiRNAs functionMotif analysisParticular lineageT lymphocyte developmentRegulatory networksLineage commitmentMiRNA targetome
2017
Developmentally regulated higher-order chromatin interactions orchestrate B cell fate commitment
Boya R, Yadavalli AD, Nikhat S, Kurukuti S, Palakodeti D, Pongubala JMR. Developmentally regulated higher-order chromatin interactions orchestrate B cell fate commitment. Nucleic Acids Research 2017, 45: 11070-11087. PMID: 28977418, PMCID: PMC5737614, DOI: 10.1093/nar/gkx722.Peer-Reviewed Original ResearchConceptsChromatin reorganizationHigher-order chromatin interactionsGenome-wide expression profilesCell fate choiceCell fate determinationCell fate commitmentHi-C analysisMulti-potent progenitorsB cell fate determinationGene expression patternsB cell fate choicesChromatin architectureGenome architectureGenome organizationChromatin interactionsTranscription regulationEpigenetic landscapeFate determinationGenomic lociFate commitmentB compartmentsCommitted stateDevelopmental switchInteraction landscapeExpression patterns