A regulatory network of microRNAs confers lineage commitment during early developmental trajectories of B and T lymphocytes
Nikhat S, Yadavalli AD, Prusty A, Narayan PK, Palakodeti D, Murre C, Pongubala JMR. A regulatory network of microRNAs confers lineage commitment during early developmental trajectories of B and T lymphocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2104297118. PMID: 34750254, PMCID: PMC8609617, DOI: 10.1073/pnas.2104297118.Peer-Reviewed Original ResearchConceptsMultipotent progenitorsCell type-specific genesDe novo motif analysisLymphocyte developmentLineage-inappropriate genesHematopoietic multipotent progenitorsSilencing of genesType-specific genesGene expression programsNovo motif analysisEarly T-lymphocyte developmentAlternate cell fatesCell-autonomous mannerGene expression patternsLineage determinantsMyeloid differentiation potentialExpression programsCell fateMiRNAs functionMotif analysisParticular lineageT lymphocyte developmentRegulatory networksLineage commitmentMiRNA targetome