2009
Antiangiogenic Strategies for the Treatment of Gliomas
Bazzoli E, Omuro A. Antiangiogenic Strategies for the Treatment of Gliomas. 2009, 243-263. DOI: 10.1007/978-1-4419-0410-2_12.Peer-Reviewed Original ResearchMalignant gliomasAntiangiogenic strategiesVascular endothelial growth factor (VEGF) pathwayEndothelial growth factor pathwayNew antiangiogenic treatmentsRecurrent malignant gliomaProgression-free survivalVEGF monoclonal antibodyInitial clinical benefitTreatment of gliomaHigh response rateGrowth factor pathwaysDifferent molecular driversMost patientsSurvival benefitClinical benefitAntiangiogenic treatmentAntiangiogenic drugsAntiangiogenesis treatmentResponse rateSolid tumorsComplex biologic processClinical settingFactor pathwayGliomas
2007
Editorial: what is new in the treatment of gliomas?
Omuro AM, Delattre JY. Editorial: what is new in the treatment of gliomas? Current Opinion In Neurology 2007, 20: 704-707. PMID: 17992093, DOI: 10.1097/wco.0b013e3282f1beef.Peer-Reviewed Original ResearchConceptsTreatment of gliomaTherapeutic decisionsEvidence-based therapeutic decisionsBevacizumab-based combinationsRecurrent malignant gliomaRole of chemotherapyPhase II trialStandard of carePhase III evidenceHigh response ratePhase II resultsSingle positive resultTemozolomide concomitantTemozolomide schedulesII trialSurvival benefitRandomized trialsGrade IIIMalignant gliomasResponse rateGliomasSuch trialsTraditional treatmentTrialsCodeletion statusMolecular genetic markers as predictors of response to chemotherapy in gliomas
Idbaih A, Omuro A, Ducray F, Hoang-Xuan K. Molecular genetic markers as predictors of response to chemotherapy in gliomas. Current Opinion In Oncology 2007, 19: 606-611. PMID: 17906460, DOI: 10.1097/cco.0b013e3282f075f3.Peer-Reviewed Original ResearchConceptsAnaplastic oligodendroglial tumorsLow-grade gliomasProspective trialMGMT statusOligodendroglial tumorsIndependent favorable prognostic factorFavorable prognostic factorRelevant prognostic markerPredictors of responsePromoter methylationTreatment of gliomaPredictor of chemosensitivityMGMT promoter methylationObjective responsePrognostic factorsRetrospective studyPrognostic markerSuch tumorsTreatment decisionsChromosome 1p/19q codeletionMGMT inactivationPredictive valueChemotherapyGliomasLow expression