Primary CNS lymphoma in patients younger than 60: can whole-brain radiotherapy be deferred?
Omuro A, Taillandier L, Chinot O, Sierra del Rio M, Carnin C, Barrie M, Soussain C, Tanguy ML, Choquet S, Leblond V, Hoang-Xuan K, On behalf of the ANOCEF Group (French Neuro-Oncology Association).. Primary CNS lymphoma in patients younger than 60: can whole-brain radiotherapy be deferred? Journal Of Neuro-Oncology 2010, 104: 323-330. PMID: 21170569, DOI: 10.1007/s11060-010-0497-x.Peer-Reviewed Original ResearchConceptsWhole brain radiotherapyHigh-dose chemotherapyProgression-free survivalPrimary central nervous system lymphomaSalvage whole brain radiotherapyComplete responseOverall survivalNeurotoxicity riskMedian progression-free survivalCentral nervous system lymphomaAdditional chemotherapy cyclesEffective salvage treatmentMedian overall survivalStem cell rescuePrimary CNS lymphomaNervous system lymphomaObjective of treatmentChemosensitive diseaseChemosensitive patientsChemotherapy cyclesInduction chemotherapyBrain radiotherapyCNS lymphomaObjective responseSalvage treatment