2022
NIMG-02. PACS-INTEGRATED AUTO-SEGMENTATION WORKFLOW FOR BRAIN METASTASES USING NNU-NET
Jekel L, Bousabarah K, Lin M, Merkaj S, Kaur M, Avesta A, Aneja S, Omuro A, Chiang V, Scheffler B, Aboian M. NIMG-02. PACS-INTEGRATED AUTO-SEGMENTATION WORKFLOW FOR BRAIN METASTASES USING NNU-NET. Neuro-Oncology 2022, 24: vii162-vii162. PMCID: PMC9661012, DOI: 10.1093/neuonc/noac209.622.Peer-Reviewed Original ResearchMachine Learning Applications for Differentiation of Glioma from Brain Metastasis—A Systematic Review
Jekel L, Brim WR, von Reppert M, Staib L, Petersen G, Merkaj S, Subramanian H, Zeevi T, Payabvash S, Bousabarah K, Lin M, Cui J, Brackett A, Mahajan A, Omuro A, Johnson MH, Chiang VL, Malhotra A, Scheffler B, Aboian MS. Machine Learning Applications for Differentiation of Glioma from Brain Metastasis—A Systematic Review. Cancers 2022, 14: 1369. PMID: 35326526, PMCID: PMC8946855, DOI: 10.3390/cancers14061369.Peer-Reviewed Original ResearchBrain metastasesDifferentiation of gliomasMagnetic resonance imagingEligible studiesSystematic reviewSingle-center institutionConventional magnetic resonance imagingSpecific clinical circumstancesNon-invasive differentiationQuality of reportingClinical circumstancesPoor reportingClinical practiceModel assessmentResonance imagingMetastasisStudy designGliomasTRIPOD StatementMultiple studiesExternal validationClinical translationAdherenceDifferentiationReview
2019
Complications associated with immunotherapy for brain metastases.
Tran TT, Jilaveanu LB, Omuro A, Chiang VL, Huttner A, Kluger HM. Complications associated with immunotherapy for brain metastases. Current Opinion In Neurology 2019, 32: 907-916. PMID: 31577604, PMCID: PMC7398556, DOI: 10.1097/wco.0000000000000756.Peer-Reviewed Original ResearchConceptsBrain metastasesNeurologic toxicityImmune therapyPhase 2 clinical trialCheckpoint inhibitor therapyImmune checkpoint inhibitorsMultiple phase 2 clinical trialsTreatment-related morbidityBrain metastatic diseaseSymptomatic edemaCheckpoint inhibitorsAdverse eventsDurable responsesMedian survivalMetastatic diseaseInhibitor therapyMore patientsIntracranial activityPatient groupRadiation necrosisClinical trialsTherapy trialsMultidisciplinary teamMetastasisPatients
2017
Cerebrospinal Fluid Circulating Tumor Cells: A Novel Tool to Diagnose Leptomeningeal Metastases from Epithelial Tumors (P5.170)
Lin X, Fleisher M, Rosenblum M, lin O, Briggs S, Boire A, Bensman Y, Hurtado B, DeAngelis L, Panageas K, Shagabayeva L, Omuro A, Pentsova E. Cerebrospinal Fluid Circulating Tumor Cells: A Novel Tool to Diagnose Leptomeningeal Metastases from Epithelial Tumors (P5.170). Neurology 2017, 88 DOI: 10.1212/wnl.88.16_supplement.p5.170.Peer-Reviewed Original ResearchDynamic contrast‐enhanced MRI perfusion for differentiating between melanoma and lung cancer brain metastases
Hatzoglou V, Tisnado J, Mehta A, Peck KK, Daras M, Omuro AM, Beal K, Holodny AI. Dynamic contrast‐enhanced MRI perfusion for differentiating between melanoma and lung cancer brain metastases. Cancer Medicine 2017, 6: 761-767. PMID: 28303695, PMCID: PMC5387174, DOI: 10.1002/cam4.1046.Peer-Reviewed Original ResearchConceptsMelanoma brain metastasesNSCLC brain metastasesLung cancer brain metastasesBrain metastasesCancer brain metastasesCell lung cancer brain metastasesDCE-MRIPrimary brain tumorsDifferent primary sitesImportant clinical implicationsMann-Whitney U testVolume transfer coefficientTumor histologyMultiple malignanciesMRI perfusionBrain tumorsMetastasisPrimary siteConventional MRIClinical implicationsPerfusion parametersTumor microvasculatureROC analysisU testPlasma volume
2015
Prospective validation of cerebrospinal fluid (CSF) circulating tumor cells (CTC) to diagnose leptomeningeal metastasis (LM) from epithelial tumors.
Lin X, Fleisher M, Omuro A, Shagabayeva L, Pentsova E. Prospective validation of cerebrospinal fluid (CSF) circulating tumor cells (CTC) to diagnose leptomeningeal metastasis (LM) from epithelial tumors. Journal Of Clinical Oncology 2015, 33: 2072-2072. DOI: 10.1200/jco.2015.33.15_suppl.2072.Peer-Reviewed Original ResearchDetection of cerebral spinal fluid (CSF) circulating melanoma cells (CMC) for the diagnosis of melanoma leptomeningeal metastasis (LM).
Lin X, Fleisher M, Shagabayeva L, Omuro A, Pentsova E. Detection of cerebral spinal fluid (CSF) circulating melanoma cells (CMC) for the diagnosis of melanoma leptomeningeal metastasis (LM). Journal Of Clinical Oncology 2015, 33: e13061-e13061. DOI: 10.1200/jco.2015.33.15_suppl.e13061.Peer-Reviewed Original Research
2013
Rare cell capture technology for the diagnosis of leptomeningeal metastasis in solid tumors
Nayak L, Fleisher M, Gonzalez-Espinoza R, Lin O, Panageas K, Reiner A, Liu CM, DeAngelis LM, Omuro A. Rare cell capture technology for the diagnosis of leptomeningeal metastasis in solid tumors. Neurology 2013, 80: 1598-1605. PMID: 23553479, PMCID: PMC3662321, DOI: 10.1212/wnl.0b013e31828f183f.Peer-Reviewed Original ResearchConceptsLeptomeningeal metastasesSolid tumorsCSF CTCsCSF pleocytosisLumbar punctureConventional cytologyRare cell capture technologyEarly diagnostic confirmationInitial MRI evaluationRepeat lumbar puncturePresence of CTCsClinical suspicionMRI evaluationPatient cohortDiagnostic confirmationCSF samplesPatientsTumorsCTC resultsTumor cellsPilot studyPleocytosisMetastasisCTCsPunctureAn Open-Label, Multi-Center, Phase II Study of Patupilone (EPO906), in the Treatment of Recurrent or Progressive Brain Metastases in Patients with Non-Small Cell Lung Cancer (NSCLC) (IN10-2.005)
Nayak L, Abrey L, DeAngelis L, Gadgeel S, Garst J, Govindan R, Kelly K, Omuro A, Peereboom D, Ramnath N, Reimers H, Rigas J, Robbins H, Rosenfeld S, Wen P. An Open-Label, Multi-Center, Phase II Study of Patupilone (EPO906), in the Treatment of Recurrent or Progressive Brain Metastases in Patients with Non-Small Cell Lung Cancer (NSCLC) (IN10-2.005). Neurology 2013, 80 DOI: 10.1212/wnl.80.7_supplement.in10-2.005.Peer-Reviewed Original ResearchAn Open-Label, Multi-Center, Phase II Study of Patupilone (EPO906), in the Treatment of Recurrent or Progressive Brain Metastases in Patients with Non-Small Cell Lung Cancer (NSCLC) (S56.002)
Nayak L, Abrey L, DeAngelis L, Gadgeel S, Garst J, Govindan R, Kelly K, Omuro A, Peereboom D, Ramnath N, Reimers H, Rigas J, Robbins H, Rosenfeld S, Wen P. An Open-Label, Multi-Center, Phase II Study of Patupilone (EPO906), in the Treatment of Recurrent or Progressive Brain Metastases in Patients with Non-Small Cell Lung Cancer (NSCLC) (S56.002). Neurology 2013, 80 DOI: 10.1212/wnl.80.7_supplement.s56.002.Peer-Reviewed Original Research
2010
Neurological Complications of Non-Hodgkin Lymphoma
Khasraw M, Noy A, Gilbert M, Omuro A. Neurological Complications of Non-Hodgkin Lymphoma. 2010, 267-285. DOI: 10.1007/978-1-4419-7668-0_16.Peer-Reviewed Original ResearchNon-Hodgkin lymphomaPeripheral nervous systemBrain metastasesCNS involvementCNS prophylaxisDirect complicationsNeurological complicationsParaneoplastic disordersPeripheral neuropathyLeptomeningeal metastasesNeurological symptomsHodgkin's lymphomaRisk factorsNervous systemComplicationsNHLLymphomaMetastasisInvolvementMyelopathyPlexopathyProphylaxisNeuropathyDirect involvementSymptoms
2005
Ventriculoperitoneal shunt in patients with leptomeningeal metastasis
Omuro AM, Lallana EC, Bilsky MH, DeAngelis LM. Ventriculoperitoneal shunt in patients with leptomeningeal metastasis. Neurology 2005, 64: 1625-1627. PMID: 15883329, DOI: 10.1212/01.wnl.0000160396.69050.dc.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBrainBrain NeoplasmsBreast NeoplasmsCarcinomaFemaleHumansHydrocephalusIntracranial HypertensionLung NeoplasmsMagnetic Resonance ImagingMaleMeningeal NeoplasmsMiddle AgedNeoplasm MetastasisPalliative CarePrognosisSubarachnoid SpaceSurvival RateTomography, X-Ray ComputedTreatment OutcomeVentriculoperitoneal ShuntConceptsLeptomeningeal metastasesPrognosis of LMEffective palliative toolMedian overall survivalProcedure-related mortalityVP shunt placementOverall survivalIntracranial hypertensionShunt placementVentriculoperitoneal shuntVP shuntPalliative toolSubdural hematomaShunt malfunctionPatientsMetastasisShunt
2004
Brain metastases
Omuro AM, Abrey LE. Brain metastases. Current Neurology And Neuroscience Reports 2004, 4: 205-210. PMID: 15102346, DOI: 10.1007/s11910-004-0040-6.Peer-Reviewed Original ResearchConceptsWhole brain radiotherapyBrain metastasesBrain radiotherapyPerformance statusPoor prognosisSystemic diseaseFocal therapyAggressive focal therapiesGood performance statusImportant prognostic factorTreatment of recurrenceLong-term survivorsStandard of careTypes of tumorsPrognostic factorsTreatment of cancerPatient populationTreatment decisionsCognitive deteriorationLocal controlMetastasisPatientsPrognosisRadiotherapyTherapy