2016
Long-term survival in AIDS-related primary central nervous system lymphoma
Gupta NK, Nolan A, Omuro A, Reid EG, Wang CC, Mannis G, Jaglal M, Chavez JC, Rubinstein PG, Griffin A, Abrams DI, Hwang J, Kaplan LD, Luce JA, Volberding P, Treseler PA, Rubenstein JL. Long-term survival in AIDS-related primary central nervous system lymphoma. Neuro-Oncology 2016, 19: 99-108. PMID: 27576871, PMCID: PMC5193026, DOI: 10.1093/neuonc/now155.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyWhole brain radiotherapyPrimary central nervous system lymphomaCentral nervous system lymphomaAR-PCNSLNervous system lymphomaHD-MTXLong-term survivalMulticenter analysisSystem lymphomaAdvent of cARTLong-term disease-free survivalLonger progression-free survivalSan Francisco General HospitalHigh-dose methotrexateDisease-free survivalProgression-free survivalOptimal therapeutic approachTherapy-related factorsFirst-line interventionPost-cART eraLong-term toxicityAntiretroviral therapyBrain radiotherapyFavorable survival
2015
First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis
Kasenda B, Ferreri A, Marturano E, Forst D, Bromberg J, Ghesquieres H, Ferlay C, Blay J, Hoang-Xuan K, Pulczynski E, Fosså A, Okoshi Y, Chiba S, Fritsch K, Omuro A, O'Neill B, Bairey O, Schandelmaier S, Gloy V, Bhatnagar N, Haug S, Rahner S, Batchelor T, Illerhaus G, Briel M. First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis. Annals Of Oncology 2015, 26: 1305-1313. PMID: 25701456, PMCID: PMC4735103, DOI: 10.1093/annonc/mdv076.Peer-Reviewed Original ResearchConceptsKarnofsky performance scoreElderly PCNSL patientsFirst-line therapyHD-MTXIndividual patient dataPCNSL patientsImproved survivalEligible studiesElderly primary central nervous system lymphoma (PCNSL) patientsPrimary central nervous system lymphoma (PCNSL) patientsPrimary central nervous system lymphomaSystematic reviewCentral nervous system lymphomaHigh-dose methotrexatePatient dataWhole brain radiotherapyFirst-line treatmentNervous system lymphomaStrong prognostic factorElderly patientsImmunocompetent patientsProspective trialMedian ageOral chemotherapyPrognostic factors
2011
Cognitive functions in primary CNS lymphoma after single or combined modality regimens
Correa DD, Shi W, Abrey LE, Deangelis LM, Omuro AM, Deutsch MB, Thaler HT. Cognitive functions in primary CNS lymphoma after single or combined modality regimens. Neuro-Oncology 2011, 14: 101-108. PMID: 22013168, PMCID: PMC3245999, DOI: 10.1093/neuonc/nor186.Peer-Reviewed Original ResearchConceptsWhole brain radiotherapyPrimary CNS lymphomaQuality of lifeHD-MTXWhite matter diseaseModality regimenCNS lymphomaHigh-dose methotrexate-based chemotherapyCognitive impairmentExtensive white matter diseaseMethotrexate-based chemotherapySubset of patientsBaseline neuropsychological evaluationBrain radiotherapyDisease remissionModality regimensMost cognitive domainsStandard treatmentTreatment completionCognitive dysfunctionSufficient severityPatientsNeuropsychological evaluationCognitive functionSubstantial risk