Outcomes of Pharmacokinetically (PK) Directed Busulfan in Combination with Thiotepa & Cyclophosphamide (TBC) Conditioning with HDT-ASCT in Patients with Primary & Secondary CNS Lymphoma
Bhatt V, Scordo M, Hsu M, Omuro A, DeAngelis L, Lin A, Matasar M, Dahi P, Moskowitz C, Giralt S, Sauter C. Outcomes of Pharmacokinetically (PK) Directed Busulfan in Combination with Thiotepa & Cyclophosphamide (TBC) Conditioning with HDT-ASCT in Patients with Primary & Secondary CNS Lymphoma. Blood 2015, 126: 1994. DOI: 10.1182/blood.v126.23.1994.1994.Peer-Reviewed Original ResearchHDT-ASCTIdeal body weightComplete remissionPartial remissionBody weightBusulfan/cyclophosphamide conditioningAutologous stem cell transplantationSecondary CNS lymphomaTransplant related mortalityHigh-dose therapyStem cell infusionStem cell transplantationBU AUCCyclophosphamide conditioningHCT-CIChemosensitive patientsFirst remissionPrior therapyRemission inductionCNS lymphomaFirst doseTarget AUCCell infusionMedian ageDosage adjustment