2022
Machine Learning Applications for Differentiation of Glioma from Brain Metastasis—A Systematic Review
Jekel L, Brim WR, von Reppert M, Staib L, Petersen G, Merkaj S, Subramanian H, Zeevi T, Payabvash S, Bousabarah K, Lin M, Cui J, Brackett A, Mahajan A, Omuro A, Johnson MH, Chiang VL, Malhotra A, Scheffler B, Aboian MS. Machine Learning Applications for Differentiation of Glioma from Brain Metastasis—A Systematic Review. Cancers 2022, 14: 1369. PMID: 35326526, PMCID: PMC8946855, DOI: 10.3390/cancers14061369.Peer-Reviewed Original ResearchBrain metastasesDifferentiation of gliomasMagnetic resonance imagingEligible studiesSystematic reviewSingle-center institutionConventional magnetic resonance imagingSpecific clinical circumstancesNon-invasive differentiationQuality of reportingClinical circumstancesPoor reportingClinical practiceModel assessmentResonance imagingMetastasisStudy designGliomasTRIPOD StatementMultiple studiesExternal validationClinical translationAdherenceDifferentiationReview
2015
First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis
Kasenda B, Ferreri A, Marturano E, Forst D, Bromberg J, Ghesquieres H, Ferlay C, Blay J, Hoang-Xuan K, Pulczynski E, Fosså A, Okoshi Y, Chiba S, Fritsch K, Omuro A, O'Neill B, Bairey O, Schandelmaier S, Gloy V, Bhatnagar N, Haug S, Rahner S, Batchelor T, Illerhaus G, Briel M. First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis. Annals Of Oncology 2015, 26: 1305-1313. PMID: 25701456, PMCID: PMC4735103, DOI: 10.1093/annonc/mdv076.Peer-Reviewed Original ResearchConceptsKarnofsky performance scoreElderly PCNSL patientsFirst-line therapyHD-MTXIndividual patient dataPCNSL patientsImproved survivalEligible studiesElderly primary central nervous system lymphoma (PCNSL) patientsPrimary central nervous system lymphoma (PCNSL) patientsPrimary central nervous system lymphomaSystematic reviewCentral nervous system lymphomaHigh-dose methotrexatePatient dataWhole brain radiotherapyFirst-line treatmentNervous system lymphomaStrong prognostic factorElderly patientsImmunocompetent patientsProspective trialMedian ageOral chemotherapyPrognostic factors
2012
First-Line Treatment and Outcome of Elderly Patients with Primary Central Nervous System Lymphoma (PCNSL) – A Systematic Review and Individual Patient Data Meta-Analysis
Kasenda B, Ferreri A, Maturano E, Bromberg J, Ghesquieres H, Ferlay C, Blay J, Xuan K, Okoshi Y, Chiba S, Fritsch K, Omuro A, O'Neill B, Bairey O, Gloy V, Bhatnagar N, Haug S, Rahner S, Illerhaus G, Briel M. First-Line Treatment and Outcome of Elderly Patients with Primary Central Nervous System Lymphoma (PCNSL) – A Systematic Review and Individual Patient Data Meta-Analysis. Blood 2012, 120: 3655. DOI: 10.1182/blood.v120.21.3655.3655.Peer-Reviewed Original ResearchPrimary central nervous system lymphomaIndividual patient dataCentral nervous system lymphomaElderly PCNSL patientsMedian age 68Improved overall survivalFirst-line treatmentNervous system lymphomaOverall survivalElderly patientsPCNSL patientsSystematic reviewEligible studiesPerformance statusSystem lymphomaFunctional statusAge 68Patient dataBetter outcomesIndividual Patient Data Meta-AnalysisDifferent first-line treatmentsMultivariable Cox regression modelsFollowing baseline characteristicsImmunocompetent PCNSL patientsCo-morbidity index