2015
Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo
Venneti S, Dunphy MP, Zhang H, Pitter KL, Zanzonico P, Campos C, Carlin SD, La Rocca G, Lyashchenko S, Ploessl K, Rohle D, Omuro AM, Cross JR, Brennan CW, Weber WA, Holland EC, Mellinghoff IK, Kung HF, Lewis JS, Thompson CB. Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo. Science Translational Medicine 2015, 7: 274ra17. PMID: 25673762, PMCID: PMC4431550, DOI: 10.1126/scitranslmed.aaa1009.Peer-Reviewed Original ResearchConceptsPositron emission tomographyPermeable blood-brain barrierChemo/radiation therapyHigh tumor/background ratiosClear tumor delineationDecreased tumor burdenHigh background uptakeTumor/background ratiosBlood-brain barrierAltered glucose metabolismHuman glioma patientsVivo positron emission tomographyProgressive diseaseTumor burdenMetabolic evaluationBrain uptakeClinical managementTumor avidityGlioma patientsRadiation therapyGlucose metabolismBackground uptakeEmission tomographyGliomasCancer cells
2014
TM-15GLUTAMINE BASED PET IMAGING FACILITATES ENHANCED METABOLIC DETECTION OF GLIOMAS IN VIVO
Venneti S, Dunphy M, Zhang H, Pitter K, Campos C, Carlin S, Lyashchenko S, Plöessl C, Rohle D, Omuro A, Cross J, Brennan C, Weber W, Holland E, Mellinghoff I, Kung H, Lewis J, Thompson C. TM-15GLUTAMINE BASED PET IMAGING FACILITATES ENHANCED METABOLIC DETECTION OF GLIOMAS IN VIVO. Neuro-Oncology 2014, 16: v216-v216. PMCID: PMC4218624, DOI: 10.1093/neuonc/nou278.14.Peer-Reviewed Original ResearchChemo/radiation therapyClear tumor delineationGlioma animal modelPlasma amino acidsClinical managementIDH1 mutant gliomasAltered glutamine metabolismRadiation therapyAnimal modelsHuman gliomasPten-nullGliomasHigh avidityPET imagingLow uptakeDetection of gliomaTumor delineationHigh uptakeAnaplerotic substrateGlutamine metabolismMetabolic stateVivoBrainGlutamine uptakeMetabolism