2014
Clinical course and progression-free survival of adult intracranial and spinal ependymoma patients
Vera-Bolanos E, Aldape K, Yuan Y, Wu J, Wani K, Necesito-Reyes MJ, Colman H, Dhall G, Lieberman FS, Metellus P, Mikkelsen T, Omuro A, Partap S, Prados M, Robins HI, Soffietti R, Wu J, Gilbert MR, Armstrong TS. Clinical course and progression-free survival of adult intracranial and spinal ependymoma patients. Neuro-Oncology 2014, 17: 440-447. PMID: 25121770, PMCID: PMC4483095, DOI: 10.1093/neuonc/nou162.Peer-Reviewed Original ResearchConceptsProgression-free survivalClinical courseEpendymoma patientsMultivariate Cox proportional hazards modelMultivariate Cox proportional hazardsCox proportional hazards modelRare CNS tumorsTime of diagnosisPrognostic clinical factorsCox proportional hazardsProportional hazards modelSubtotal resectionClinical factorsMedian timeCNS tumorsCentral reviewGrade IIIMean ageTumor recurrenceEarly progressionTumor locationGrade IITumor gradeUnivariate analysisSupratentorial location
2012
A prognostic gene expression signature in infratentorial ependymoma
Wani K, Armstrong TS, Vera-Bolanos E, Raghunathan A, Ellison D, Gilbertson R, Vaillant B, Goldman S, Packer RJ, Fouladi M, Pollack I, Mikkelsen T, Prados M, Omuro A, Soffietti R, Ledoux A, Wilson C, Long L, Gilbert MR, Aldape K, For the Collaborative Ependymoma Research Network. A prognostic gene expression signature in infratentorial ependymoma. Acta Neuropathologica 2012, 123: 727-738. PMID: 22322993, PMCID: PMC4013829, DOI: 10.1007/s00401-012-0941-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAntigens, NeoplasmChildCluster AnalysisDatabases, GeneticDNA Topoisomerases, Type IIDNA-Binding ProteinsEpendymomaFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansInfratentorial NeoplasmsLongitudinal StudiesMaleOligonucleotide Array Sequence AnalysisPrognosisReproducibility of ResultsSex FactorsSurvival AnalysisYoung AdultConceptsRecurrence-free survivalInfratentorial ependymomaClinical outcomesReal-time reverse transcriptase-polymerase chain reaction assaysReverse transcriptase-polymerase chain reaction assaysGroup 1 tumorsPrognostic gene expression signaturesTranscriptase-polymerase chain reaction assaysGroup 2 tumorsGene expression subgroupsPolymerase chain reaction assaysClinical factorsGene expression signaturesIndependent predictorsPrognostic significanceInfratentorial compartmentHistological factorsClinical behaviorChain reaction assaysClinical aggressivenessPrognostic signatureExpression subgroupsEpendymomaMolecular alterationsMultivariate analysis