2017
Mitogen-Activated Protein Kinase Regulation in Hepatic Metabolism
Lawan A, Bennett AM. Mitogen-Activated Protein Kinase Regulation in Hepatic Metabolism. Trends In Endocrinology And Metabolism 2017, 28: 868-878. PMID: 29128158, PMCID: PMC5774993, DOI: 10.1016/j.tem.2017.10.007.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseMitogen-activated protein kinaseHepatic metabolismLipid metabolismType 2 diabetes mellitusFatty liver diseaseHepatic mitogen-activated protein kinaseHepatic metabolic functionDiabetes mellitusLiver diseaseLiver metabolismMetabolic diseasesInsulin actionPathophysiological conditionsDiseaseMetabolismMetabolic functionsRecent insightsMellitusObesityProtein kinase
2011
Loss of Mitogen-activated Protein Kinase Phosphatase-1 Protects from Hepatic Steatosis by Repression of Cell Death-inducing DNA Fragmentation Factor A (DFFA)-like Effector C (CIDEC)/Fat-specific Protein 27*
Flach RJ, Qin H, Zhang L, Bennett AM. Loss of Mitogen-activated Protein Kinase Phosphatase-1 Protects from Hepatic Steatosis by Repression of Cell Death-inducing DNA Fragmentation Factor A (DFFA)-like Effector C (CIDEC)/Fat-specific Protein 27*. Journal Of Biological Chemistry 2011, 286: 22195-22202. PMID: 21521693, PMCID: PMC3121364, DOI: 10.1074/jbc.m110.210237.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinase phosphatase-1Hepatic lipid homeostasisFatty acid oxidationLipid homeostasisMKP-1-deficient miceProtein kinase phosphatase-1MAPK-dependent phosphorylationFat-specific protein 27Like effector CPeroxisome proliferator-activated receptor-γ target genesProtein 27Kinase phosphatase-1Lipid droplet formationPhosphatase 1Acid oxidationLipogenic gene expressionSerine 112Target genesHepatic lipogenic gene expressionGene expressionPPARγ functionMetabolic signalsInhibitory residuesFactor AHepatic fatty acid oxidation
1993
Calcium as a permissive factor but not an initiation factor in DNA synthesis induction in cultured rat hepatocytes by the peroxisome proliferator ciprofibrate
Bennett A, Williams G. Calcium as a permissive factor but not an initiation factor in DNA synthesis induction in cultured rat hepatocytes by the peroxisome proliferator ciprofibrate. Biochemical Pharmacology 1993, 46: 2219-2227. PMID: 8274155, DOI: 10.1016/0006-2952(93)90612-z.Peer-Reviewed Original ResearchAlteration of rat liver endoplasmic reticulum Ca2+-ATPase thiol integrity by ciprofibrate, a peroxisome proliferator
Bennett A, Williams G. Alteration of rat liver endoplasmic reticulum Ca2+-ATPase thiol integrity by ciprofibrate, a peroxisome proliferator. Biochemical Pharmacology 1993, 45: 2093-2098. PMID: 8512590, DOI: 10.1016/0006-2952(93)90021-n.Peer-Reviewed Original Research
1992
Reduction of rat liver endoplasmic reticulum Ca2+-ATPase activity and mobilization of hepatic intracellular calcium by ciprofibrate, a peroxisome proliferator
Bennett A, Williams G. Reduction of rat liver endoplasmic reticulum Ca2+-ATPase activity and mobilization of hepatic intracellular calcium by ciprofibrate, a peroxisome proliferator. Biochemical Pharmacology 1992, 43: 595-605. PMID: 1531754, DOI: 10.1016/0006-2952(92)90583-5.Peer-Reviewed Original ResearchConceptsATPase protein contentFree intracellular calcium concentrationLiver endoplasmic reticulumLiver microsomal Ca2Control levelsSingle oral doseMale F344 ratsIntracellular calcium concentrationEffect of ciprofibrateDose-dependent inhibitionControls 24 hrConcentration-dependent inhibitionEndoplasmic reticulum Ca2ATPase activityOral doseF344 ratsIntracellular calciumExtracellular calciumMicrosomal Ca2Peroxisome proliferatorTransient decreaseHepatic endoplasmic reticulumFunctional inhibitionMitogenic responseRats