1993
Calcium as a permissive factor but not an initiation factor in DNA synthesis induction in cultured rat hepatocytes by the peroxisome proliferator ciprofibrate
Bennett A, Williams G. Calcium as a permissive factor but not an initiation factor in DNA synthesis induction in cultured rat hepatocytes by the peroxisome proliferator ciprofibrate. Biochemical Pharmacology 1993, 46: 2219-2227. PMID: 8274155, DOI: 10.1016/0006-2952(93)90612-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCells, CulturedClofibric AcidDNADrug SynergismEgtazic AcidFibric AcidsLiverMaleMicrobodiesRatsRats, Inbred F344ConceptsHepatocyte DNA synthesisAlteration of rat liver endoplasmic reticulum Ca2+-ATPase thiol integrity by ciprofibrate, a peroxisome proliferator
Bennett A, Williams G. Alteration of rat liver endoplasmic reticulum Ca2+-ATPase thiol integrity by ciprofibrate, a peroxisome proliferator. Biochemical Pharmacology 1993, 45: 2093-2098. PMID: 8512590, DOI: 10.1016/0006-2952(93)90021-n.Peer-Reviewed Original Research
1992
Reduction of rat liver endoplasmic reticulum Ca2+-ATPase activity and mobilization of hepatic intracellular calcium by ciprofibrate, a peroxisome proliferator
Bennett A, Williams G. Reduction of rat liver endoplasmic reticulum Ca2+-ATPase activity and mobilization of hepatic intracellular calcium by ciprofibrate, a peroxisome proliferator. Biochemical Pharmacology 1992, 43: 595-605. PMID: 1531754, DOI: 10.1016/0006-2952(92)90583-5.Peer-Reviewed Original ResearchConceptsATPase protein contentFree intracellular calcium concentrationLiver endoplasmic reticulumLiver microsomal Ca2Control levelsSingle oral doseMale F344 ratsIntracellular calcium concentrationEffect of ciprofibrateDose-dependent inhibitionControls 24 hrConcentration-dependent inhibitionEndoplasmic reticulum Ca2ATPase activityOral doseF344 ratsIntracellular calciumExtracellular calciumMicrosomal Ca2Peroxisome proliferatorTransient decreaseHepatic endoplasmic reticulumFunctional inhibitionMitogenic responseRats